Category Archives: Prevention

Maternal HIV infection and antiretroviral therapy in pregnancy: Implications for vertical transmission, fetal safety, and long-term infant outcomes

2025

HIV mother-to-child transmission (MTCT) continues to pose a significant public health challenge, especially in regions with limited resources, although the worldwide distribution of antiretroviral therapy (ART) has drastically lowered the...

Lenacapavir: A twice-yearly injectable for HIV preexposure prophylaxis

2025

OBJECTIVE: To review the efficacy and safety of lenacapavir for the prevention of HIV-1 infection. DATA SOURCES: Clinical trials and review articles were obtained through August 2025 using search terms...

Oral pre-exposure prophylaxis retention among men who have sex with men and transgender persons: Systematic review and meta-analysis

2025

Successful implementation of oral pre-exposure prophylaxis (PrEP) requires retention in PrEP care among those with an increased likelihood of HIV. This study aimed to estimate the proportion of retention on...

A scoping review of grey zone use for transfusion-transmitted infection screening among blood donors

2025

BACKGROUND AND OBJECTIVES: Screening for transfusion-transmitted infections (TTIs) among blood donors is done using qualitative screening assays. Screening values that are close to cut-off values lie in the uncertainty zone,...

Motivations, facilitators, and barriers of donation-based interventions in HIV and sexually transmitted infection research: A systematic review

2025

IMPORTANCE: Donation-based prosocial interventions involve someone receiving a free health service and then distributing or donating to support health services for others; examples within the HIV and sexually transmitted infection...

Seroprevalence of transfusion-transmitted infections among blood donors in India: A systematic review and meta-analysis

2025

BACKGROUND AND OBJECTIVES: Blood transfusion is essential in healthcare but carries inherent risks of human immunodeficiency virusAÿ(HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), syphilis and malaria transmission. National...

Immunogenicity and safety of the booster COVID-19 vaccine among people with HIV: A systematic review and meta-analysis

2025

Background Human immunodeficiency virus (HIV) and COVID-19 continue to pose significant global public health challenges. Although vaccination is essential for preventing COVID-19 in people with HIV (PWH), evidence on the...

Breastfeeding knowledge, attitudes and practices of HIV-positive women in Africa: A systematic review

2025

BACKGROUND: Breastfeeding is essential for ensuring the health and survival of children, particularly in regions where diarrhoea, pneumonia and malnutrition are common causes of child mortality. In sub-Saharan Africa, over...

Performance of adherence measures for oral, tenofovir-based HIV pre-exposure prophylaxis: A systematic review

2025

Accurate adherence measures to HIV pre-exposure prophylaxis (PrEP) are essential for identifying individuals with low adherence and providing tailored support. This systematic review summarizes evidence on the performance of PrEP...

Prevalence and factors influencing HIV testing behavior in adolescents and young adults: A systematic review and meta-analysis

2025

Objective To systematically evaluate the prevalence and influencing factors of human immunodeficiency virus (HIV) testing among adolescents and young adults (10–25 years old), providing a reference for optimizing testing strategies and...

Male circumcision and HIV risk compensation among men who have sex with men: A systematic review and meta-analysis

2025

Male circumcision (MC) has been shown to reduce the risk of HIV infection among men who have sex with men (MSM) in a recent randomised controlled trial. A question that...

Network meta-analytical investigations of the performance of HIV combination prevention strategies for Indigenous populations

2025

BACKGROUND: Indigenous populations worldwide face a disproportionate burden of HIV due to structural inequities, cultural marginalization, and limited access to health services. Despite growing recognition of the need for culturally...

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