Category Archives: Prevention
Vending machines for reducing harm associated with substance use and use disorders, and co-occurring conditions: A systematic review
Background To stem rising fatal overdoses and other substance use/use disorder (SUD)-related harms, communities are turning to low-barrier harm reduction strategies, such as harm reduction-focused vending machines (VMs) that distribute...
Interventions to improve HIV care continuum outcomes for people with HIV who have incarceration experience: A narrative review
People with HIV who are reentering the community after incarceration encounter multiple barriers to engagement in HIV care and treatment. We conducted a narrative review of recent interventions (2020-2023) developed...
Sexually transmitted and blood-borne infections in transgender and non-binary people in Canada: A scoping review
In the 2021 census, 100,815 people in Canada aged 15 and older identified as transgender or non-binary. Globally, transgender people are disproportionately burdened by several Sexually Transmitted and Blood-Borne Infections...
Preexposure prophylaxis and intimate partner violence among gay, bisexual, and other men who have sex with men: A global scoping review of the literature
Men who have sex with men (MSM) experience intimate partner violence (IPV) and are at an elevated risk of HIV acquisition. Preexposure prophylaxis (PrEP) is an effective preventative measure against...
Better together?: A systematic review of he effectiveness of HIV prevention interventions that build or strengthen social ties
Although social relationships impact health and social dynamics play a key role in shaping HIV vulnerability, results from intentional efforts to build or strengthen social relationships have not been synthesized...
Safer opioid supply clients’ values and preferences: A systematic review and thematic synthesis of qualitative research
QUESTION: What are the values and preferences of safer opioid supply clients? STUDY SELECTION AND ANALYSIS: We conducted a systematic review of qualitative studies on safer opioid supply client experiences...
Assessing the impact of digital communication tools on oral PrEP adherence: A systematic review and meta-analysis
This systematic review and meta-analysis evaluated the effect of digital communication tools (e.g., text message reminders) on improving daily oral HIV pre-exposure prophylaxis (PrEP) adherence. Searching PubMed, Embase, Web of...
Knowledge, attitudes, and willingness of healthcare workers to offer pre-exposure prophylaxis in Africa: A systematic review and meta-analysis
Background Despite advancements in HIV prevention strategies, including pre-exposure prophylaxis (PrEP), uptake remains suboptimal in high-burden regions like Africa. Healthcare workers (HCWs) play a pivotal role in PrEP implementation. This...
Effects of test-and-treat versus preexposure prophylaxis on elimination of HIV transmission: Analysis of 24 HIV prevention trials
INTRODUCTION: In 2023, 28.8 million (72%) of 39.9 million people with HIV (PWH) worldwide were on treatment with viral suppression, while 11.1 million (28%) people had viraemia with the risk...
Descriptions of risks and benefits of HIV vaccine trials in low-and middle-income countries (LMICs): An integrative review
Human immunodeficiency virus (HIV) vaccine trials are needed in efforts to prevent infection and acquired immunodeficiency syndrome (AIDS). Like other types of research, HIV vaccine trials present benefits and risks...
Analysis of the effect of the COVID-19 pandemic on syphilis in susceptible populations: Me who have sex with men, people living with HIV, and patients with gestational and congenital syphilis—A narrative review
The COVID-19 pandemic triggered a public health crisis that significantly impacted sexually transmitted infections (STIs), particularly syphilis. However, data on syphilis incidence during the pandemic remains inconsistent globally. Key groups...
Free antiretrovirals as a key tool against the HIV pandemic: A systematic review
BACKGROUND/OBJECTIVES: Access to antiretroviral (ARV) drugs remains a critical challenge in achieving the WHO/UNAIDS 95-95-95 targets, with medication costs representing a substantial barrier. This systematic review evaluates the effect of...
