Category Archives: Biomedical interventions
The effect of probiotics, prebiotics, and synbiotics on cd4 counts in HIV-infected patients: A systematic review and meta-analysis
BACKGROUND: Probiotics as a potential adjuvant therapy may improve the restoration of the intestinal CD4(+) T-cell population in HIV-infected patients, whereas findings from clinical trials are inconsistent. This systematic review...
Approaches to transitioning women into and out of prevention of mother-to-child transmission of HIV services for continued ART: A systematic review
Introduction: Women living with HIV are required to transition into the prevention of mother-to-child transmission of HIV (PMTCT) services when they become pregnant and back to ART services after delivery....
Prevalence of pretreatment HIV drug resistance in key populations: A systematic review and meta-analysis
Introduction: WHO’s 2019 report on HIV drug resistance (HIVDR) documents a high prevalence of pretreatment drug resistance (PDR) among populations initiating first-line antiretroviral therapy (ART) in low- and middle-income countries...
Mapping evidence of mobile health technologies for disease diagnosis and treatment support by health workers in sub-Saharan Africa: A scoping review
BACKGROUND: The rapid growth of mobile technology has given rise to the development of mobile health (mHealth) applications aimed at treating and preventing a wide range of health conditions. However,...
A scoping review of HIV pre-exposure prophylaxis stigma and implications for stigma-reduction interventions for men and transwomen who have sex with men
HIV remains a public health concern in the United States. Although pre-exposure prophylaxis (PrEP) can be expected to reduce HIV incidence, its uptake, adherence, and persistence remain limited, particularly among...
Isoniazid preventive therapy plus antiretroviral therapy for the prevention of tuberculosis: A systematic review and meta-analysis of individual participant data
Background: Isoniazid preventive therapy prevents active tuberculosis in people with HIV, but previous studies have found no evidence of benefit in people with HIV who had a negative tuberculin skin...
An in-depth analysis of novel combinatorial drug therapy via nanocarriers against HIV/AIDS infection and their clinical perspectives: A systematic review
INTRODUCTION: Conventional antiretroviral therapy against HIV infections is threatening to become outdated due to the low chemical, physical, biological, and pharmacokinetic characteristics of therapeutic molecules, followed by the high chance...
Understanding Mental Health in the Context of Adolescent Pregnancy and HIV in Sub-Saharan Africa: A Systematic Review Identifying a Critical Evidence Gap
Adolescent (10–19 years) mental health remains an overlooked global health issue. Rates of adolescent pregnancy within sub-Saharan Africa are some of the highest in the world and occur at the...
The effects of HIV self-testing on the uptake of HIV testing, linkage to antiretroviral treatment and social harms among adults in Africa: A systematic review and meta-analysis
INTRODUCTION: HIV infection is still a global public health problem. More than 75% of HIV-infected people are in Africa, and up to 54% are unaware of their HIV status, limiting...
Pre-exposure prophylaxis care continuum, barriers, and facilitators among Black men who have sex with men in the United States: A systematic review and meta-analysis
Pre-exposure prophylaxis (PrEP) represents a viable HIV prevention tool for black men who have sex with men (BMSM). However, aggregated evidence regarding the presentations and determinants of the PrEP continuum...
Measles seroprevalence and vaccine responses in human immunodeficiency virus-infected adolescents and adults: A systematic review
BACKGROUND: The World Health Organization (WHO) recommends an additional dose of measles-containing vaccine (MCV) for human immunodeficiency virus (HIV)-infected children receiving highly active antiretroviral therapy following immune reconstitution. We conducted...
