Category Archives: Biomedical interventions

Eliciting Preferences for HIV Prevention Technologies: A Systematic Review

2021

BACKGROUND: Many human immunodeficiency virus (HIV) prevention technologies (pre-exposure prophylaxis, microbicides, vaccines) are available or in development. Preference elicitation methods provide insight into client preferences that may be used to...

Immunogenicity of pneumococcal vaccination in HIV infected individuals: A systematic review and meta-analysis

2020

Background: The objective of this systematic review and meta-analysis was to summarise the literature regarding the immunogenicity of pneumococcal conjugate vaccines (PCV) and pneumococcal polysaccharide vaccines (PPSV) in adult people...

The effect of probiotics, prebiotics, and synbiotics on cd4 counts in HIV-infected patients: A systematic review and meta-analysis

2020

BACKGROUND: Probiotics as a potential adjuvant therapy may improve the restoration of the intestinal CD4(+) T-cell population in HIV-infected patients, whereas findings from clinical trials are inconsistent. This systematic review...

Mapping evidence of mobile health technologies for disease diagnosis and treatment support by health workers in sub-Saharan Africa: A scoping review

2021

BACKGROUND: The rapid growth of mobile technology has given rise to the development of mobile health (mHealth) applications aimed at treating and preventing a wide range of health conditions. However,...

A scoping review of HIV pre-exposure prophylaxis stigma and implications for stigma-reduction interventions for men and transwomen who have sex with men

2021

HIV remains a public health concern in the United States. Although pre-exposure prophylaxis (PrEP) can be expected to reduce HIV incidence, its uptake, adherence, and persistence remain limited, particularly among...

Isoniazid preventive therapy plus antiretroviral therapy for the prevention of tuberculosis: A systematic review and meta-analysis of individual participant data

2021

Background: Isoniazid preventive therapy prevents active tuberculosis in people with HIV, but previous studies have found no evidence of benefit in people with HIV who had a negative tuberculin skin...

The effects of HIV self-testing on the uptake of HIV testing, linkage to antiretroviral treatment and social harms among adults in Africa: A systematic review and meta-analysis

2021

INTRODUCTION: HIV infection is still a global public health problem. More than 75% of HIV-infected people are in Africa, and up to 54% are unaware of their HIV status, limiting...

Pre-exposure prophylaxis care continuum, barriers, and facilitators among Black men who have sex with men in the United States: A systematic review and meta-analysis

2021

Pre-exposure prophylaxis (PrEP) represents a viable HIV prevention tool for black men who have sex with men (BMSM). However, aggregated evidence regarding the presentations and determinants of the PrEP continuum...

An in-depth analysis of novel combinatorial drug therapy via nanocarriers against HIV/AIDS infection and their clinical perspectives: A systematic review

2021

INTRODUCTION: Conventional antiretroviral therapy against HIV infections is threatening to become outdated due to the low chemical, physical, biological, and pharmacokinetic characteristics of therapeutic molecules, followed by the high chance...

Understanding Mental Health in the Context of Adolescent Pregnancy and HIV in Sub-Saharan Africa: A Systematic Review Identifying a Critical Evidence Gap

2021

Adolescent (10–19 years) mental health remains an overlooked global health issue. Rates of adolescent pregnancy within sub-Saharan Africa are some of the highest in the world and occur at the...

Interventions for immigrant Latino men who have sex with men along the HIV prevention and treatment cascade

2020

Key take-home messages Among reported HIV cases with a known race/ethnicity in Canada in 2017, 6.3% were among individuals from Latin America. In 2018, Latinx persons in the U.S. were...

Effectiveness of take-home naloxone programs and availability of naloxone nasal spray in different jurisdictions

2020

Key take-home messages There is wide support of take-home naloxone programs as they are associated with decreased mortality, but there is some evidence that take-home naloxone alone may not be...

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