Category Archives: Biomedical interventions
Risk of failure in dual therapy versus triple therapy in naive HIV-patients: A systematic review and meta-analysis
BACKGROUND: Several attempts have been made to test different drug-sparing strategies to reduce the drug-burden and drug-related toxicities. OBJECTIVE: The objective of this meta-analysis was to evaluate the relative risk...
Efficacy of HIV interventions in African fishing communities: A systematic review and qualitative synthesis
OBJECTIVES: This systematic review aims to qualitatively synthesise existing evidence on the efficacy of HIV interventions in African fishing communities. METHODS: Five databases (NCBI PubMed, EMBASE, Web of Science Core...
Nature of, and responses to key sexual and reproductive health challenges for adolescents in urban slums in sub-Saharan Africa: A scoping review
BACKGROUND: Addressing adolescents’ sexual and reproductive health and rights (SRHR) requires an understanding of the socio-cultural and spatial settings within which they live. One setting of particular importance is the...
Diagnostic infectious diseases testing outside clinics: A global systematic review and meta-analysis
BACKGROUND: Most people around the world do not have access to facility-based diagnostic testing, and the gap in availability of diagnostic tests is a major public health challenge. Self-testing, self-sampling,...
Impact of human immunodeficiency virus (HIV) infection in patients undergoing cardiac surgery: A systematic review
The clinical status and prognosis of patients with human immunodeficiency virus (HIV) infection has dramatically changed in the recent years. Cardiovascular diseases can be related to combined antiretroviral therapy and...
Meta-synthesis of qualitative research of pre-exposure prophylaxis (PrEP) adherence among men who have sex with men (MSM)
The aim of the study was to consolidate evidence on barriers and facilitators to PrEP adherence among men who have sex with men. PubMed, Science Direct, and EBSCO host were...
Effect of vitamin D, selenium, or zinc supplementation in HIV: A systematic review
We conducted a systematic review to examine evidence from randomized controlled trials studying the effect of Vitamin D, selenium, or zinc supplementation in human immunodeficiency virus (HIV). An electronic literature...
The effect of successful antiretroviral therapy on immune activation and Reconstitution in HIV infected adults: A systematic review and meta-analysis
We performed a systematic review and meta-analysis to investigate the impact of antiretroviral therapy (ART) on immune activation and reconstitution in people living with human immunodeficiency virus (PLWH). The PubMed...
Summary of the NACI systematic review and recommendation on the use of live attenuated influenza vaccine (LAIV) in HIV-infected individuals
BACKGROUND: Annual influenza vaccination is recommended for all individuals six months of age and older, including those with HIV infection. Prior to this statement, the National Advisory Committee on Immunization...
Efficacy and safety of doravirine in treatment-naive HIV-1-infected adults: a systematic review and meta-analysis
This research aims to study the safety and efficacy of doravirine in the treatment of HIV-1 (human immunodeficiency virus) patients. We conducted an electronic search in eight databases for the...