Category Archives: Biomedical interventions

The potential cost-effectiveness of HIV vaccines: A systematic review

2017

OBJECTIVE: The aim of this paper was to review and compare HIV vaccine cost-effectiveness analyses and describe the effects of uncertainty in model, methodology, and parameterization. METHODS: We systematically searched...

Postnatal HIV transmission in breastfed infants of HIV-infected women on ART: A systematic review and meta-analysis

2017

INTRODUCTION: To systematically review the literature on mother-to-child transmission in breastfed infants whose mothers received antiretroviral therapy and support the process of updating the World Health Organization infant feeding guidelines...

Safety of tenofovir disoproxil fumarate-based antiretroviral therapy regimens in pregnancy for HIV-infected women and their infants: A systematic review and meta-analysis

2017

BACKGROUND: There are limited data on adverse effects of tenofovir disoproxil fumarate (TDF)-based antiretroviral therapy (ART) on pregnant women and their infants. METHODS: We conducted a systematic review of studies...

Economic impact of routine opt-out antenatal HIV screening: A systematic review

2017

OBJECTIVES: To evaluate the economic impact of routine testing of HIV in antenatal (ANC) settings. BACKGROUND: Many children are being infected with HIV through mother to child transmission (MTCT) of...

A global estimate of the acceptability of pre-exposure prophylaxis for HIV among men who have sex with men: A systematic review and meta-analysis

2017

Pre-exposure prophylaxis (PrEP) is a new biomedical intervention for HIV prevention. This study systematically reviews the acceptability of PrEP among men who have sex with men (MSM) worldwide. We searched...

Improving outpatient implementation of preexposure prophylaxis in men who have sex with men

2016

BACKGROUND AND PURPOSE: Preexposure prophylaxis (PrEP) has been shown to decrease the transmission of human immunodeficiency virus (HIV) when used in high-risk populations including men who have sex with men....

Systematic review of sex work interventions in sub-Saharan Africa: Examining combination prevention approaches

2017

OBJECTIVE: The incidence of HIV and sexually transmitted infections is disproportionately high among sex workers (SW). We aimed to update the evidence on the effectiveness of SW interventions in sub-Saharan...

New challenges in therapeutic vaccines against HIV infection

2017

INTRODUCTION: There is a growing interest in developing curative strategies for HIV infection. Therapeutic vaccines are one of the most promising approaches. We will review the current knowledge and the...

Performance of virological testing for early infant diagnosis: A systematic review

2017

BACKGROUND: Improved access to both maternal antiretroviral therapy (ART) and infant prophylaxis may have an impact on the performance of virological assays for diagnosis of HIV infection in infants. This...

Pre-exposure prophylaxis for HIV prevention: Safety concerns

2017

Available evidence supports the efficacy of pre-exposure prophylaxis (PrEP) in decreasing the incidence of human immunodeficiency virus (HIV) infection among high-risk individuals, especially when used in combination with other behavioural...

What is the relationship between increased access to HAART, relationship status and fertility decisions amongst HIV positive women? A literature review and meta-analysis

2017

AIMS AND OBJECTIVES: To investigate the relationship between fertility decisions, to have already had a child or to desire to have one in the future, and the prognostic factors of;...

Barriers and enablers of the prevention of mother-to-child transmission of HIV/AIDS program in China: A systematic review and policy implications

2017

OBJECTIVE: To identify the barriers to and enablers of the prevention of mother-to-child transmission (PMTCT) of HIV program in China. METHODS: A systematic review of the existing literature regarding barriers...

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