Category Archives: Biomedical interventions

Male circumcision for prevention of homosexual acquisition of HIV in men

2011

BACKGROUND: Previous systematic reviews found inconsistent effects of male circumcision on HIV acquisition in men who have sex with men (MSM). However, a number of new studies have become available...

Comparisons of disparities and risks of HIV infection in black and other men who have sex with men in Canada, UK, and USA: A meta-analysis

2012

BACKGROUND: We did a meta-analysis to assess factors associated with disparities in HIV infection in black men who have sex with men (MSM) in Canada, the UK, and the USA....

Microbicide acceptability research: Current approaches and future directions

2005

With growing recognition of the potential value of microbicides for HIV/STI prevention, the importance of the acceptability of this brand-new technology has been widely acknowledged. We review the current body...

Meta-analysis of published studies or meta-analysis of individual data? Caesarean section in HIV-positive women as a study case

2003

Very few comparative evaluations of meta-analysis of published data and meta-analysis using individual patient data have appeared in the medical literature. The association between type of delivery and HIV perinatal...

The magnitude of loss to follow-up of HIV-exposed infants along the prevention of mother-to-child HIV transmission continuum of care: A systematic review and meta-analysis

2013

INTRODUCTION: Although prevention of mother-to-child HIV transmission (PMTCT) programs are widely implemented, many children do not benefit from them because of loss to follow-up (LTFU). We conducted a systematic review...

Effects of postnatal interventions for the reduction of vertical HIV transmission on infant growth and non-HIV infections: A systematic review

2013

INTRODUCTION: Guidelines in resource-poor settings have progressively included interventions to reduce postnatal HIV transmission through breast milk. In addition to HIV-free survival, infant growth and non-HIV infections should be considered....

Safety of task-shifting for male medical circumcision: A systematic review and meta-analysis

2012

INTRODUCTION: Task-shifting for male medical circumcision is proposed as a strategy to overcome the lack of surgeons and doctors in high HIV prevalence settings. We undertook a systematic review and...

Population-based biomedical sexually transmitted infection control interventions for reducing HIV infection

2011

BACKGROUND: The transmission of sexually transmitted infections (STIs) is closely related to the sexual transmission of human immunodeficiency virus (HIV). Similar risk behaviours, such as frequent unprotected intercourse with different...

A systematic review of the quality of trials evaluating biomedical HIV prevention interventions shows that many lack power

2009

Purpose: Several randomized, controlled trials (RCTs) have tested strategies to prevent sexual acquisition of HIV infection, but their quality has been variable. We aimed to identify, describe, and evaluate the...

Improving the prevention, diagnosis and treatment of TB among people living with HIV: The role of operational research

2011

Operational research is necessary to improve the access to and delivery of tuberculosis prevention, diagnosis and treatment interventions for people living with HIV. We conducted an extensive review of the...

Interventions to prevent sexually transmitted infections, including HIV infection

2011

The Centers for Disease Control and Prevention (CDC) Sexually Transmitted Disease (STD) Treatment Guidelines were last updated in 2006. To update the “Clinical Guide to Prevention Services” section of the...

Randomized controlled trials of individual-level, population-level, and multilevel interventions for preventing sexually transmitted infections: What has worked?

2005

BACKGROUND: Previous reviews of interventions to prevent sexually transmitted infections (STIs) focused mostly on human immunodeficiency virus (HIV) infection. We reviewed trials of interventions to prevent sexual transmission of any...

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