Category Archives: Health Systems
Virtual care pathways for people living with HIV: A mixed-methods systematic review
BACKGROUND: The COVID-19 pandemic prompted an unprecedented surge in virtual services, necessitating a rapid shift to digital healthcare approaches. This review focuses on evaluating the evidence of virtual care (VC)...
Social network-based approaches to HIV testing: A systematic review and meta-analysis
INTRODUCTION: Social network-based testing approaches (SNAs) encourage individuals (“test promoters”) to motivate sexual partners and/or those in their social networks to test for HIV. We conducted a systematic review to...
Identifying effective strategies for improving engagement in HIV prevention and care among transgender persons in the United States: A systematic review
This systematic review synthesized published literature (2000–2023) to identify HIV interventions specifically designed for transgender persons in the United States (PROSPERO registration number: CRD42021256460). The review also summarized strategies for...
State of HIV costing in Latin America and the Caribbean: A systematic literature review
OBJECTIVES: To summarize available data on unit costs for human immunodeficiency virus (HIV) testing, prevention, and care interventions in Latin America and the Caribbean. METHODS: We conducted a systematic literature...
Innovative pre-exposure prophylaxis interventions among adolescent girls and young women during COVID-19 lockdown period in sub-Saharan Africa: A systematic review
Adolescent girls and young women are key, and priority populations impacted by a higher risk of acquiring human immunodeficiency virus. In 2015, pre-exposure prophylaxis was introduced as a biomedical human...
Pre-exposure Prophylaxis (PrEP) implementation among latino MSM: A qualitative scoping review of implementation determinants and change methods
INTRODUCTION: The increasing rates of HIV among Latino men who have sex with men (MSM) necessitate innovative and rigorous studies to evaluate prevention and treatment strategies. Pre-exposure prophylaxis (PrEP) is...
Treatment failure among Sub-Sahara African children living with HIV: A systematic review and meta-analysis
BACKGROUND: Antiretroviral treatment failure is a global issue, particularly in developing countries such as Sub-Saharan Africa. Prior research findings were highly variable and inconsistent across areas. As a result, the...
Exploring intervention frameworks to improve utilization of elimination of mother-to-child transmission services in Africa: A scoping review
BACKGROUND: Over the past two decades, intervention strategies to improve the use of the elimination of mother-to-child transmission (EMTCT) services have been implemented for several reasons. The reasons include elimination...
Adverse perinatal outcomes associated with different classes of antiretroviral drugs in pregnant women living with HIV: A systematic review and meta-analysis
OBJECTIVE: Women living with HIV (WLHIV) are at increased risk of adverse perinatal outcomes compared to HIV-negative women, despite antiretroviral therapy (ART). There is evidence that the risk of adverse...
Acceptability and use of HIV self-testing among young people in sub-Saharan Africa: A mixed methods systematic review
Background Young people (YP) are disproportionately affected by the HIV pandemic in sub-Saharan Africa (SSA), but testing rates remain low despite global targets of testing 95% of people with HIV...
Neuropsychiatric adverse events in tenofovir disoproxil fumarate- and tenofovir alafenamide-based HIV therapy and prophylaxis: A systematic review and meta-analysis
INTRODUCTION: Tenofovir is integral to antiretroviral therapy (ART) and preexposure prophylaxis (PrEP) for HIV, but its neuropsychiatric adverse events (NPAEs) have not been systematically investigated. OBJECTIVES: This systematic review aims...
