Category Archives: Health Systems

Disparities in awareness, willingness and uptake of biomedical HIV prevention among bisexual and gay men: A systematic review and meta-analysis

2026

INTRODUCTION: The field of HIV/STI prevention research has primarily focused on gay men, leaving bisexual men overshadowed in broader discussions on sexual minority men’s health. Although also at increased risk...

The global re-emergence of syphilis and antimicrobial resistance among men who have sex with men (MSM), people living with HIV (PLWH), and newborns: A narrative review

2026

Syphilis incidence continues to rise substantially among men who have sex with men (MSM), people living with HIV (PLWH), newborns, and women of reproductive age, despite preventive measures and available...

The mental health of adults living with HIV in sub-Saharan Africa: Interventions along the HIV care continuum—A systematic review

2026

Although the relationship between HIV and mental health is well-established, limited research has focused on the available interventions for adults living with HIV (ALWH), particularly those in sub-Saharan Africa (SSA)...

Can ChatGPT match physicians in the diagnosis, triage, management and prevention of infectious diseases? A scoping review

2026

INTRODUCTION: The global burden of infectious diseases (ID), combined with a shortage of ID specialists, continues to challenge healthcare systems worldwide. Artificial intelligence (AI), particularly large language models such as...

Facilitators and barriers to cervical cancer screening among women living with HIV: A systematic review of qualitative studies

2026

BACKGROUND: Evidence suggests that 58% of new cervical cancer cases worldwide occur among women living with HIV. However, compared with HIV-negative women, this population has significantly poorer access to healthcare...

Integration of HIV, Hepatitis B, and C, and sexually transmitted infections services: A scoping review of the benefits and challenges

2026

BACKGROUND: Integrating clinical programs and services is a cost-effective approach that can improve health and system outcomes. This review aimed to provide an overview of the benefits and challenges of...

Interventions to improve access to sexual and reproductive health services for adolescents living with HIV in sub-Saharan Africa: A scoping review

2026

OBJECTIVE: Adolescents living with HIV (ALHIV) face barriers to accessing sexual and reproductive health (SRH) services, negatively affecting their health and quality of life. These challenges are particularly pronounced in...

Exploring the potential of cognitive intra-individual variability in HIV care and research in adults with HIV: A concept analysis

2026

Cognitive intraindividual variability (IIV) refers to the variability in one’s ability to sustain consistent cognitive performance. This phenomenon is linked to the emergence of cognitive impairment and dementia. The aim...

Effectiveness of digital health interventions for improving antiretroviral therapy outcomes in people with HIV: Meta-analysis and trial sequential analysis of randomized controlled trials

2026

Background: Digital health interventions (DHIs) are increasingly used to support antiretroviral therapy (ART) management among people living with HIV. However, existing systematic reviews have largely focused on single intervention types or...

Impact of dolutegravir-based regimens on patient satisfaction and quality of life among people living with HIV: A systematic review and meta-analysis

2026

Background Despite the global scale up of dolutegravir (DTG)-based regimens as the preferred first-line therapy for persons living with HIV (PLHIV), no comprehensive evidence exists on its effect on patient-reported...

Structural competency as a global framework for syndemic HIV care: A critical synthesis

2026

The co-occurrence of HIV with mental health disorders, substance use, and tuberculosis continues to constitute significant global public health issues. Syndemic theory elucidates how these conditions interact synergistically to exacerbate...

Peer-led models for improving HIV treatment and care outcomes among adolescents and young people living with HIV in eastern and southern Africa: A rapid review

2026

Adolescents and Young People Living with HIV have poor levels of adherence to treatment and retention in care. Previous reviews highlighted the need for high-quality evidence on peer-led interventions for...

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