Category Archives: Health Systems
Implementation of therapeutic adherence in adult patients diagnosed with the human immunodeficiency virus: A systematic review
OBJECTIVES: To systematically map and summarize the available knowledge on interventions that promote medication adherence among adult HIV patients and to describe the current state of the art regarding the...
Prevalence and risk factors for oropharyngeal, esophageal, and oral candidiasis in HIV-positive individuals: A systematic review and meta-analysis
Background:Â Oral, oropharyngeal, and esophageal candidiasis are common forms of mucosal candidiasis (MC) in people living with human immunodeficiency virus/acquired immunodeficiency syndrome (PLWHA). Despite differences in infection sites, oral, oropharyngeal, and...
Indirect treatment comparison of the efficacy of long-acting injectable cabotegravir compared with lenacapavir for HIV pre-exposure prophylaxis
INTRODUCTION: Long-acting injectable cabotegravir (hereafter referred to as cabotegravir) is the first long-acting injectable approved for pre-exposure prophylaxis (PrEP) based on the HPTN 083 and 084 trials. Long-acting injectable lenacapavir...
Screening for asymptomatic sexually transmitted infections in emergency departments: An integrative review of public health outcomes
OBJECTIVE: To synthesise evidence on opportunistic screening for asymptomatic sexually transmitted infections and bloodborne viruses (STI/BBV) in emergency departments (EDs), focusing on detection, public health outcomes and feasibility. METHODS: An...
Effectiveness of digital health interventions on antiretroviral therapy adherence among people living with HIV in India: A systematic review with an RCT-only meta-analysis
The widespread use of combination antiretroviral therapy has transformed HIV infection into a chronic condition, with life expectancy of people with HIV (PWH) approaching that of the general population when...
Effects of targeted interventions on HIV testing, knowledge and sexual risk behaviours among long-distance truck drivers: A systematic review and meta-analysis
Objectives We aimed to systematically summarise and quantify the empirical evidence on targeted interventions and their effects on various HIV prevention outcomes for long-distance truck drivers (LDTDs) globally. Design A...
Integrated service delivery models for triple elimination of mother to child transmission of human immunodeficiency virus, syphilis, and hepatitis B virus: A global systematic review and meta-analysis
BACKGROUND AND OBJECTIVES: Despite global commitment to the World Health Organization triple elimination initiative, evidence on integrated antenatal service delivery models that simultaneously address human immunodeficiency virus (HIV), syphilis, and...
Maternal, fetal, and neonatal outcomes of additional dihydroartemisinin-piperaquine to trimethoprim-sulfamethoxazole in intermittent preventive treatment for malaria in HIV-positive pregnancies: A systematic review and meta-analysis
PURPOSE: This systematic review evaluates the addition of Dihydroartemisinin-Piperaquine (DHA-PPQ) to Trimethoprim-Sulfamethoxazole (TMP-SMX) for Intermittent Preventive Treatment (IPT) in HIV-positive pregnancies, focusing on its effects on malaria infection, maternal adverse...
Perspective of people living with HIV and healthcare workers on the uptake, barriers, and benefits of multimonth dispensing: A qualitative systematic review
INTRODUCTION: Multimonth dispensing (MMD) is a strategy in the HIV care continuum for people living with HIV (PLWH), especially for those who are virally suppressed. With the increase in MMD...
The burden of HIV-related stigma on clinical and quality of life outcomes: results from a systematic literature review
BACKGROUND: HIV-related stigma adversely impacts people with HIV. As part of a systematic literature review (SLR) to evaluate 6 research questions on HIV-related stigma among people with HIV, data from...
Simulation modeling for the design and evaluation of HIV drug resistance interventions: A systematic review of literature
Background The utility of antiretroviral therapy (ART) in the management of human immunodeficiency virus (HIV) is being challenged by growing HIV drug resistance (HIVDR). Although simulation modelling is useful for...
The gut-immune axis in treated HIV infection: From mucosal damage to chronic inflammation and therapeutic opportunities—A clinician-oriented narrative review
Combined antiretroviral therapy (cART) has transformed HIV into a manageable chronic disease. However, people living with HIV (PLWH) experience a 16-year reduction in comorbidity-free life expectancy compared to HIV-negative individuals,...
