Category Archives: Health Systems

Where are the pregnant and breastfeeding women in new pre-exposure prophylaxis trials? The imperative to overcome the evidence gap

2022

Pregnant and breastfeeding populations are at substantial risk of acquiring HIV in some settings, yet are underrepresented in clinical trials of new pre-exposure prophylaxis (PrEP) agents. Several PrEP formulations are...

Care of sexual and gender minorities in the emergency department: A scoping review

2022

STUDY OBJECTIVE: This scoping review was conducted to collate and summarize the published research literature addressing sexual and gender minority care in the emergency department (ED). METHODS: Using PRISMA-ScR criteria,...

Vaginal ring acceptability: A systematic review and meta-analysis of vaginal ring experiences from around the world

2022

OBJECTIVE: The vaginal ring (ring) is a female-initiated, long-acting drug delivery system for different indications, including HIV prevention. Our aim was to provide evidence for acceptability of the vaginal ring...

Acceptability of HIV pre-exposure prophylaxis in China: A systematic review and meta-analysis

2022

Using pre-exposure prophylaxis (PrEP) for the prevention of HIV infection is a popular, contemporary research topic. We retrieved PubMed, Web of Science, MEDLINE, Wanfang, CNKI, and Sinomed databases, and related...

A systematic review of linkage-to-care and antiretroviral initiation implementation strategies in low- and middle-income countries across sub-Saharan Africa

2022

Linkage to care (LTC) and initiation of antiretroviral therapy (ART) are key components in the longitudinal care cascade for people living with HIV. Many strategies to optimize these stages of...

Cost-effectiveness of HIV retention and re-engagement interventions in high-income countries: A systematic literature review

2022

Engagement in lifelong HIV care is critical for both patient and public health, yet there are limited resources to invest in improving HIV outcomes. We systematically reviewed evidence on the...

Challenges and opportunities for hepatitis B cure in the setting of HIV–Hepatitis B virus co-infection

2020

PURPOSE OF REVIEW: To examine issues specific to HIV–HBV co-infection that are relevant to the search for and achieving hepatitis B cure in this the setting RECENT FINDINGS: In HIV–HBV...

Enhancing care for people living with HIV: Current and future monitoring approaches

2021

INTRODUCTION: Antiretroviral therapy (ART) is the most significant advance in the medical management of HIV-1 infection. Given the fact that HIV cannot be eradicated from the body, ART has to...

Low inducibility of latent human immunodeficiency virus type 1 proviruses as a major barrier to cure

2021

The latent reservoir for human immunodeficiency virus type 1 (HIV-1) in resting CD4+ T cells is a major barrier to cure. The dimensions of the reservoir problem can be defined...

The OATH syndemic: Opioids and other substances, aging, alcohol, tobacco, and HIV

2020

PURPOSE OF REVIEW: Persons living with HIV (PLWH) are aging, continue to use alcohol and other substances, and experience age-associated adverse effects. We explore a new syndemic: OATH (opioids and...

A review of the state of the science of HIV and stigma: Context, conceptualization, measurement, interventions, gaps, and future priorities

2021

Stigma is a fundamental cause of health inequities. As such, stigma is a major barrier to HIV prevention, care, and treatment. This review will examine the concept of stigma, explicating...

The role of oxidative stress in HIV-associated neurocognitive disorders

2021

HIV-associated neurocognitive disorders (HAND) are a leading cause of morbidity in up to 50% of individuals living with HIV, despite effective treatment with antiretroviral therapy (ART). Current evidence suggests that...

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