Category Archives: Health Systems

Academic detailing to increase prescribing of HIV pre-exposure prophylaxis

2021

Although HIV pre-exposure prophylaxis can decrease new cases of HIV by up to 99%, many patients who could benefit from pre-exposure prophylaxis never receive prescriptions for it. Because pre-exposure prophylaxis...

Efficacy and safety of triple versus dolutegravir-based dual therapy in patients with HIV-1 infection: A meta-analysis of randomized controlled trials

2021

A new strategy of simplification therapy shown the unique benefits in clinical treatment, by reducing pill burden and avoid drug exposure. To provide more evidence for the strategy, we compared...

Significance of the placental barrier in antenatal viral infections

2021

The placenta provides a significant physical and physiological barrier to prevent fetal infection during pregnancy. Nevertheless, it is at times breached by pathogens and leads to vertical transmission of infection...

Gut microbiome in people living with HIV is associated with impaired thiamine and folate syntheses

2021

People living with HIV have a high incidence of cardiovascular and neurological diseases as comorbid disorders that are commonly linked to inflammation. While microbial translocation can augment inflammation during HIV...

Hepatotoxicity of contemporary antiretroviral drugs

2021

PURPOSE OF REVIEW: To date, more than 30 antiretroviral drugs have been approved by the Food and Drug Administration for the treatment of HIV infection. As new drugs with better...

An update on neuropsychiatric adverse effects with second-generation integrase inhibitors and nonnucleoside reverse transcriptase inhibitors

2021

PURPOSE OF REVIEW: Neuropsychiatric adverse effects (NPAE) associated with integrase strand transfer inhibitors (INSTIs) and nonnucleoside reverse transcriptase inhibitors (NNRTIs) are a growing concern, with higher rates in the real-world...

Cause of hospitalization and death in the antiretroviral era in Sub-Saharan Africa published 2008–2018: A systematic review

2021

BACKGROUND: Worldwide despite the availability of antiretroviral therapy, human immunodeficiency virus/acquired immunodeficiency syndrome still causes morbidity and mortality among patients. In Sub-Saharan Africa, human immunodeficiency virus/acquired immunodeficiency syndrome remains a...

Stated preference research in reproductive and maternal healthcare services in sub-Saharan Africa: A systematic review

2021

BACKGROUND AND OBJECTIVE: Understanding the preferred choice of healthcare service attributes for women is important, particularly in sub-Saharan Africa where resources are constrained and improving reproductive and maternal healthcare services...

Novel platforms for biomedical HIV prevention delivery to key populations — Community mobile clinics, peer-supported, pharmacy-led PrEP delivery, and the use of telemedicine

2021

PURPOSE OF REVIEW: A gap exists between PrEP interest and PrEP uptake in key populations (KP) for HIV prevention that may be ascribed to PrEP delivery services not being acceptable....

Effectiveness of and best practices for using contingency management and incentives for health care issues related to HIV, sexually transmitted infections (STIs), and pre-exposure prophylaxis (PrEP)

2021

Using contingency management and incentives at the different steps of HIV care continuum (such as testing, treatment adherence, viral suppressions) is widely explored and discussed in the literature, whereas the...

Immediate initiation of antiretroviral therapy (ART) after HIV diagnosis

2021

The benefits of beginning antiretroviral therapy (ART) soon after HIV diagnosis include improved health outcomes across a wide variety of settings as well as decreased long term healthcare costs. Generally,...

Telemedicine for HIV care: Current status and future prospects

2021

Due to the COVID-19 pandemic, the use of telemedicine has been highlighted, especially in specialties, such as the management of HIV. Recent data were reviewed between January 1, 2019 and...

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