Category Archives: Health Systems

Approaches used to monitor the effectiveness of community-led monitoring programmes: A scoping review to inform HIV programmes

2025

INTRODUCTION: Community-led monitoring (CLM) for HIV is a technique implemented by local community-led organizations and groups that systematically gather data about HIV services to advocate for improvement. This review was...

Strategies for improving linkage to HIV care after hospital discharge among adults living with HIV in low- and middle-income countries: A systematic review

2025

Purpose Despite the availability of antiretroviral therapy (ART), nearly a quarter of people living with HIV (PLHIV) die within six months after hospital discharge due to complications from AIDS-related illnesses....

Mortality and associated factors among children with the double burden of human immunodeficiency virus and tuberculosis in African countries: A systematic review and meta-analysis

2025

Introduction The dual burden of Human Immunodeficiency Virus (HIV) and Tuberculosis (TB) in children is leading to significant mortality. Although primary studies have reported wide ranges of mortality rates among...

Motivations, facilitators, and barriers of donation-based interventions in HIV and sexually transmitted infection research: A systematic review

2025

IMPORTANCE: Donation-based prosocial interventions involve someone receiving a free health service and then distributing or donating to support health services for others; examples within the HIV and sexually transmitted infection...

Access and utilization of HIV/STI testing services among men who have sex with men during the COVID-19 pandemic: A systematic review

2025

Background: Men who have sex with men (MSM) continue to bear the disproportionate burden of HIV and other sexually transmitted infections (STIs). The public health response to the COVID-19 pandemic...

Integration of mental health and HIV service delivery in low- and middle-income countries: A systematic review of effectiveness

2025

Human immunodeficiency virus (HIV) and mental health have complex, bidirectional impacts. Integrated service delivery, especially in low- and middle-income countries (LMICs) where resources are most limited and the burden of...

Lenacapavir: A twice-yearly injectable for HIV preexposure prophylaxis

2025

OBJECTIVE: To review the efficacy and safety of lenacapavir for the prevention of HIV-1 infection. DATA SOURCES: Clinical trials and review articles were obtained through August 2025 using search terms...

High HIV viral suppression among adults receiving WHO-recommended first-line dolutegravir-based antiretroviral therapy in low- and middle-income countries: A systematic review and meta-analysis of programmatic evidence

2025

Background This systematic review and meta-analysis assessed viral suppression among adults receiving WHO-recommended first-line dolutegravir-based ART in programmatic settings in low- and middle-income countries (LMICs). Methods A systematic search of...

Characterization and risk stratification of coronary artery disease in people living with HIV: A global systematic review

2025

Background Coronary artery disease (CAD) is a leading cause of mortality among people living with HIV (PLWH). Risk stratification remains inconsistent due to geographic disparities, ART-related metabolic effects, and overreliance...

Interventions to support breastfeeding among mothers living with HIV: A systematic review and meta-analysis of randomized controlled trials

2025

BACKGROUND: Breastfeeding improves infant survival, especially in low-resource settings. Although the risk of postnatal transmission is below 1% among virologically suppressed mothers living with HIV, exclusive breastfeeding (EBF) rates and...

Maternal HIV infection and antiretroviral therapy in pregnancy: Implications for vertical transmission, fetal safety, and long-term infant outcomes

2025

HIV mother-to-child transmission (MTCT) continues to pose a significant public health challenge, especially in regions with limited resources, although the worldwide distribution of antiretroviral therapy (ART) has drastically lowered the...

Factors related to loss to follow-up among people living with HIV: A systematic review

2025

Loss to follow-up (LTFU) among people living with HIV (PLHIV) is a concerning reality in various healthcare services and can occur at any stage of HIV care. LTFU can lead...

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