Category Archives: Delivery arrangements
How care is organized
Rapid diagnostic tests, laboratory-based immunoassay and nucleic acid testing strategies for long-acting injectable pre-exposure prophylaxis: A systematic review and meta-analysis
Background Long-acting injectable pre-exposure prophylaxis (LAI-PrEP) is a highly effective biomedical intervention for the prevention of HIV acquisition. There is a strong interest among communities and policymakers for LAI-PrEP scale-up,...
Effectiveness of mobile health (mHealth) interventions on ART adherence among people living with HIV in low- and middle-income countries: A systematic review and meta-analysis
Antiretroviral therapy (ART) is essential for HIV treatment, yet maintaining high adherence remains challenging in resource-limited settings. Mobile health (mHealth) interventions offer a scalable approach to support adherence. This meta-analysis...
Worldwide changes in HIV-related stigma among people living with HIV: A cross-temporal meta-analysis and systematic review
Background: HIV-related stigma among people living with HIV has emerged as a growing public health concern, yet limited longitudinal data are available to characterize its evolution over time. In this study,...
Barriers and facilitators influencing PrEP uptake among men who have sex with men and transgender women in the United States: A systematic review
In the United States, men who have sex with men (MSM) and transgender women (TGW) have high HIV pre-exposure prophylaxis (PrEP) awareness, yet uptake rates remain extremely low. This signifies...
Incidence and predictors of loss to follow-up among adults on antiretroviral therapy in Ethiopia: A systematic review and meta-analysis of cohort studies
Background Loss to follow-up (LTFU) from antiretroviral therapy (ART) remains a major public health concern worldwide, including in Ethiopia. However, nationally representative pooled cohort data on LTFU among adults receiving...
Prevention of mother-to-child transmission of HIV in the MENA region: A systematic review with comparative evidence from sub-Saharan Africa
The Middle East and North Africa (MENA) region faces distinct challenges in addressing the HIV epidemic, including social stigma, limited surveillance data, and insufficient coverage of prevention services. Prevention of...
Factors influencing implementation of point-of-care tests for maternal and newborn screening and diagnosis in low-resource settings: A systematic review
BACKGROUND: Despite the potential of point-of-care (POC) tests to improve maternal and newborn health, implementation in low- and middle-income countries remains inconsistent. POC testing enables rapid, decentralized screening, but barriers...
PrEP delivery for U.S. adolescents and young adults: A systematic review and narrative synthesis
Despite proven efficacy in preventing human immunodeficiency virus (HIV) transmission, pre-exposure prophylaxis (PrEP) remains underutilized among adolescents and young adults (AYA) in the United States (US). This systematic review and...
Interventions to improve HIV care and treatment outcomes among people with HIV who have substance use disorder or at-risk substance use: A narrative review
Substance use adversely affects engagement in HIV care, adherence to medication, and HIV viral suppression. This review assessed the scope of US interventions designed to promote positive outcomes along the...
Inconsistent condom use and its associated factors among female sex workers in African countries: Systematic review and meta-analysis
Background Inconsistent condom use represents the most proximal behavioral risk factor for acquisition and transmission of sexually transmitted infections, including human immunodeficiency virus. However, certain situations hinder female sex workers...
Commonality and co-occurrence of discrete strategies within implementation strategy bundles: Findings from the Living Database of HIV Implementation Science systematic review, 2014-2021
Background HIV services and innovations are delivered through implementation strategy bundles that are often complex, comprising numerous discrete strategies. Systematically characterizing the use patterns of discrete strategies may inform strategy...
Understanding antiretroviral therapy adherence in children with HIV: A review of barriers and strategies
INTRODUCTION: Despite advancements in antiretroviral therapy (ART) availability, maintaining optimal adherence remains difficult, especially in low- and middle-income countries (LMICs). This literature review synthesized evidence on barriers and interventions influencing...
