Category Archives: Governance arrangements
How decisions about care are made
Effects of transition from paediatric to adult HIV care on virological outcomes in sub-Saharan Africa: A systematic review and meta-analysis
BACKGROUND: HIV remains a major global burden, with 2.4 million children and adolescents affected, 84% living in sub-Saharan Africa. As adolescents age, transitioning from paediatric to adult HIV care represents...
Rapid diagnostic tests, laboratory-based immunoassay and nucleic acid testing strategies for long-acting injectable pre-exposure prophylaxis: A systematic review and meta-analysis
BACKGROUND: Long-acting injectable pre-exposure prophylaxis (LAI-PrEP) is a highly effective biomedical intervention for the prevention of HIV acquisition. There is a strong interest among communities and policymakers for LAI-PrEP scale-up,...
Worldwide changes in HIV-related stigma among people living with HIV: A cross-temporal meta-analysis and systematic review
BACKGROUND: HIV-related stigma among people living with HIV has emerged as a growing public health concern, yet limited longitudinal data are available to characterize its evolution over time. In this...
Barriers and Facilitators Influencing PrEP Uptake Among Men Who Have Sex with Men and Transgender Women in the United States: A Systematic Review
In the United States, men who have sex with men (MSM) and transgender women (TGW) have high HIV pre-exposure prophylaxis (PrEP) awareness, yet uptake rates remain extremely low. This signifies...
A web of risk: multilevel factors and feedback loops (re)produce HIV ‘risk’ among gay, bisexual and other men who have sex with men – a global systematic review
BACKGROUND: HIV literature shows that gay, bisexual and men who have sex with other men (GBMSM) experience inequities across social and contextual factors. Given growing inequities, this study used complex...
The burden of sarcopenia in people living with HIV: a systematic review and meta-analysis across WHO regions
BACKGROUND: Sarcopenia, characterized by progressive loss of skeletal muscle mass and function, represents an underrecognized comorbidity in people living with human immunodeficiency virus, and comprehensive prevalence data across WHO regions...
HIV Mortality Surveillance in Nigeria, A Systematic Review of Trends, Determinants, and Implications For Public Health Policy
Despite substantial progress in expanding antiretroviral therapy (ART) coverage and scaling up prevention interventions, Human Immunodeficiency Virus (HIV) related mortality remains a significant public health challenge in several high-burden settings,...
Commonality and co-occurrence of discrete strategies within implementation strategy bundles: findings from the Living Database of HIV Implementation Science systematic review, 2014-2021
BACKGROUND: HIV services and innovations are delivered through implementation strategy bundles that are often complex, comprising numerous discrete strategies. Systematically characterizing the use patterns of discrete strategies may inform strategy...
Virological outcomes of dolutegravir-based versus other antiretroviral regimens in people living with HIV: A systematic review and meta-analysis
BACKGROUND: Dolutegravir (DTG) is endorsed as a preferred option for both first- and second-line antiretroviral therapy (ART); however, comprehensive high-quality evidence regarding its virological effectiveness is still limited. This review...
The Prevalence and Influencing Factors of Frailty Among Middle-Aged and Older Adults With HIV/AIDS From a Global Perspective: A Systematic Review and Meta-Analysis
AIM: Currently, frailty has become a central issue in health management among middle-aged and older people living with HIV/AIDS (PLWHA) worldwide. The objective is to develop targeted strategies to improve...
Effectiveness and safety of darunavir and lopinavir for treating children and adolescents living with HIV: a systematic review
INTRODUCTION: Darunavir and lopinavir solid formulations are recommended protease inhibitors for treating HIV. An evidence review of their effectiveness/efficacy and safety in young populations was needed to inform the 2025...
