Effects of interleukin-10 -1082G/A and -592C/A gene polymorphisms on the risk of human immunodeficiency virus-1 infection: An updated meta-analysis

This paper has aimed to review the available evidence on the association between Interleukin (IL) -10 -1082G/A, -592C/A gene polymorphisms and the risk of human immunodeficiency virus-1(HIV-1) infection. The data of PubMed updated in May 2021 were retrieved. The HIV infection risks were estimated in allelic, recessive, dominant, homozygous, heterozygous, over-dominant models of IL-10-1082G/A and-592C/A gene locus as odds ratio (OR) with the corresponding 95% confidence interval (95% CI). The correlation was not significant between -1082G/A polymorphism and HIV-1 susceptibility (allelic model (G vs. A: OR (95% CI)=0.968 (0.878–1.067)); recessive model (GG vs. AA+AG: OR (95% CI)=0.940, (0.771–1.146)); dominant model (GG+AG vs. AA: OR (95% CI)=0.967(0.846-1.106)); homozygous model (GG vs. AA: OR (95% CI)=0.971(0.780–1.209)); heterozygous model (AG vs. AA: OR (95% CI)=0.988(0.797–1.224)) and over-dominant model (GG+AA vs. AG: OR (95% CI)=0.969(0.781–1.201)). IL-10-592C/A polymorphism might be related to HIV-1 in allelic model, dominant model, homozygous model and heterozygous model (OR (95% CI)(0.796–0.965); OR (95% CI)=0.793(0.664–0.948); OR (95% CI)=0.755,(0.612–0.930); OR (95% CI)=0.820(0.679–0.991), respectively), but not to recessive model and over-dominant model (OR (95% CI)=0.882(0.770–1.010) and OR (95% CI)=1.009(0.897–1.148))

• Epidemiology and Determinants of Health
  • Epidemiology
• Population(s)
  • General HIV- population