Hepatitis C reinfection after successful treatment
Key take-home messages
- HCV reinfection rates vary widely. Reinfection depends on the extent to which an individual engages in high risk activities after having achieved sustained virologic response through treatment.
- The risk of HCV reinfection among patients who do not engage in higher-risk activities appears to be negligible.
- Some studies suggest that the risk of HCV reinfection among people who inject drugs is low but the quality of this evidence has been assessed as very low. Conversely, a recent systematic review and meta-analysis estimated that, among patients that engage in “high-risk” behaviour (e.g. people who inject drugs), the likelihood of being reinfected over a five-year period was 11%.
- The risk of HCV reinfection through sexual contact among men who have sex with men appears to be high.
- The risk of HCV reinfection among HIV co-infected patients is high.
The Ontario HIV Treatment Network: Rapid Response Service
- Epidemiology and Determinants of Health
- People who use drugs
- General HIV+ population
- General HIV- population
- Hepatitis B, C