Hepatitis C reinfection after successful treatment


Key take-home messages
  • HCV reinfection rates vary widely. Reinfection depends on the extent to which an individual engages in high risk activities after having achieved sustained virologic response through treatment.
  • The risk of HCV reinfection among patients who do not engage in higher-risk activities appears to be negligible.
  • Some studies suggest that the risk of HCV reinfection among people who inject drugs is low but the quality of this evidence has been assessed as very low. Conversely, a recent systematic review and meta-analysis estimated that, among patients that engage in “high-risk” behaviour (e.g. people who inject drugs), the likelihood of being reinfected over a five-year period was 11%.
  • The risk of HCV reinfection through sexual contact among men who have sex with men appears to be high.
  • The risk of HCV reinfection among HIV co-infected patients is high.


The Ontario HIV Treatment Network: Rapid Response Service




  • Epidemiology and Determinants of Health
    • Epidemiology
  • Population(s)
    • People who use drugs
    • General HIV+ population
    • General HIV- population
  • Co-infections
    • Hepatitis B, C


Abstract/Full paper

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