Mental disorders in HIV/HCV coinfected patients under antiviral treatment for hepatitis C


This paper aims to review the epidemiology and management of mental disorders in human immunodeficiency virus (HIV)/hepatitis C virus (HCV) coinfected patients, the need for antiviral therapy in this specific population, and current treatment strategies for HIV/HCV patients with psychiatric and/or substance use disorders. This is a narrative review. Data was sourced from electronic databases and was not limited by language or date of publication. HIV infection has become a survivable chronic illness. Prevalence of HCV infection among HIV-infected patients is high ranging from 50% to 90%. Patients with psychiatric diseases have also an increased risk for HIV/HCV coinfection. The most effective strategy to decrease HCV-related morbidity and mortality in coinfection is to achieve viral eradication. Although psychiatric symptoms often appear during antiviral treatment and may be associated with the use of interferon-alpha (IFN-alpha), recent evidence suggests that many patients with comorbid mental and substance use disorders can be treated safely. Recent data indicate that IFN-alpha-induced psychiatric side effects have a similar prevalence in HIV/HCV coinfected patients than in monoinfected patients and they can be managed and even prevented successfully with psychopharmacological strategies in the frame of a multidisciplinary team. New antivirals offer INF-free therapies for this specific population.


Martin-Subero M, Diez-Quevedo C.




  • Population(s)
    • General HIV+ population
  • Engagement and Care Cascade
    • Treatment
  • Mental Health
    • Depression
  • Co-infections
    • Hepatitis B, C


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