SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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Barriers and facilitators to healthcare access among Sub-Saharan African migrants in Europe: A scoping review

2026

Background Sub-Saharan African (SSA) migrants represent a significant and growing proportion of Europe’s diverse migrant population; yet face substantial barriers in accessing healthcare services. Understanding these barriers is essential for...

Prevalence of hypertension, diabetes, obesity, and high cholesterol among older people living with HIV: A systematic review and meta-analysis

2026

INTRODUCTION: Metabolic comorbidities are significant health challenges for older people living with HIV (PLHIV). This systematic review and meta-analysis aimed to synthesize existing evidence and provide the pooled prevalence of...

Artificial intelligence for predicting antiretroviral therapy outcomes in people living with HIV: A systematic review of predictive models, predictors and clinical readiness

2026

BACKGROUND: Machine learning (ML), deep learning (DL) and other predictive modelling approaches are increasingly applied to predict antiretroviral therapy (ART) outcomes among people living with HIV, yet their methodological robustness...

Doxycycline prophylaxis is effective as pre-exposure and post-exposure regimens in the prevention of sexually transmitted infections: An updated systematic review and meta-analysis

2026

Background: Recent systematic reviews have demonstrated the efficacy of doxycycline prophylaxis in preventing bacterial sexually transmitted infections (STIs) in randomised controlled trials (RCTs). In this review, we updated evidence from RCTs...

Commonality and co-occurrence of discrete strategies within implementation strategy bundles: Findings from the Living Database of HIV Implementation Science systematic review, 2014-2021

2026

Background HIV services and innovations are delivered through implementation strategy bundles that are often complex, comprising numerous discrete strategies. Systematically characterizing the use patterns of discrete strategies may inform strategy...

Risk of HIV transmission by healthcare workers—A systematic review

2026

BACKGROUND: Occupational HIV infection among healthcare workers (HCWs) has declined markedly in high-income countries as a result of improved infection prevention and control, safety-engineered devices, and the widespread availability of...

Efficacy and safety of doravirine/islatravir for HIV-1: A GRADE-assessed systematic review and meta-analysis of randomized controlled trials

2026

Background: The combination of doravirine and islatravir (DOR/ISL) is a novel two-drug regimen for HIV-1. Early development faced challenges due to dose-dependent immunological signals. We aimed to synthesize the evidence on...

From community engagement to lived experience leadership: A systematic review of HIV services among men who have sex with men

2026

Community responses are essential to achieving the global goal of Ending AIDS by 2030, yet men who have sex with men (MSM) remain underrepresented and often tokenized within HIV initiatives....

Temporal shifts in antiretroviral therapy regimens and metabolic outcomes in people living with HIV: A systematic review and meta-analysis

2026

Introduction Antiretroviral therapy (ART) for people living with HIV has led to dramatically reduced mortality and improved life expectancy. This achievement is accompanied by a higher risk for metabolic and...

Choosing between dual and three-drug antiretroviral therapy in aging and comorbid people with HIV: A narrative review

2026

The widespread use of combination antiretroviral therapy has transformed HIV infection into a chronic condition, with life expectancy of people with HIV (PWH) approaching that of the general population when...

Incidence and predictors of opportunistic infection among people living with HIV in Ethiopia: A systematic review and meta-analysis

2026

Background Opportunistic infections (OIs) play a crucial role in the morbidity and mortality of HIV‐infected individuals. Despite the increasing use of antiretroviral therapy, there remains a lack of comprehensive data...

Guidance on the clinical management of HIV-1 persistent low-level viraemia on antiretroviral treatment: A scoping review and an international Delphi consensus

2026

Despite the success of antiretroviral therapy, a subset of people with HIV experience low-level viraemia (LLV), a challenging condition with inconsistent definitions and management across settings. We conducted a scoping...

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