SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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Cerebrospinal fluid immune markers and HIV-associated neurocognitive impairments: A systematic review

2021

HIV-1 is responsible for the development of a spectrum of cognitive impairments known as HIV-associated neurocognitive disorder (HAND). In the era of antiretroviral therapy (ART), HAND remains prevalent in people...

Interventions addressing depression and HIV-related outcomes in people with HIV

2021

PURPOSE OF REVIEW: People with HIV (PWH) are more likely to experience depression than those without HIV. Depression is not only distressing and interfering in and of itself, but it...

The effectiveness of peer-support for people living with HIV: A systematic review and meta-analysis

2021

BACKGROUND: The practice of involving people living with HIV in the development and provision of healthcare has gained increasing traction. Peer-support for people living with HIV is assistance and encouragement...

Factors associated with methamphetamine use among men who have sex with men

2021

An abundance of literature details problematic sexualized drug use among men who have sex with men; additionally, several interventions attempt to address methamphetamine dependence in this population. Several factors are...

Safety of tenofovir disoproxil fumarate for pregnant women facing the coronavirus disease 2019 pandemic

2021

We assessed the teratogenicity of tenofovir, a human immunodeficiency virus (HIV) drug similar to remdesivir that is currently being evaluated for the treatment of coronavirus disease 2019 (COVID-19). Using US...

Sex differences in non-AIDS comorbidities among people with human immunodeficiency virus

2021

Women are grossly underrepresented in human immunodeficiency virus (HIV) clinical and translational research. This is concerning given that people with HIV (PWH) are living longer, and thus accumulating aging-related non-AIDS...

NK cell-based therapies for HIV infection: Investigating current advances and future possibilities

2021

NK cells are well-known for their antiviral functions. Also, their role in HIV has been well established, with rapid responses elicited during early HIV infection. Most immune cells including CD4(+)...

HIV-proteins-associated CNS neurotoxicity, their mediators, and alternative treatments

2021

Human immunodeficiency virus (HIV)-infected people’s livelihoods are gradually being prolonged with the use of combined antiretroviral therapy (ART). Conversely, despite viral suppression by ART, the symptoms of HIV-associated neurocognitive disorder...

Assessing proviral competence: Current approaches to evaluate HIV-1 persistence

2021

PURPOSE OF REVIEW: Despite decades of suppressive antiretroviral therapy (ART), HIV-1 reservoirs persist and fuel viral rebound if therapy is interrupted. The persistence of viral reservoirs in infected individuals is...

1,2,3-Triazole hybrids with anti-HIV-1 activity

2021

The human immunodeficiency virus type 1 (HIV-1) is the major etiological agent responsible for the acquired immunodeficiency syndrome (AIDS), which is a serious infectious disease and remains one of the...

Bibliometric analysis of HIV and exercise literature based on scientific studies from 1990–2020

2021

BACKGROUND: Exercise is believed to play an important role in maintaining functionality in patients with HIV and it is thought that researchers are increasingly interested in this field. We aimed...

Purely behavioral: A scoping review of nonpharmacological behavioral and lifestyle interventions to prevent cardiovascular disease in persons living with HIV

2021

Cardiovascular disease (CVD) is the leading cause of death in the United States, accounting for 900,000 deaths annually. People living with HIV are at a higher risk of developing CVD....

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