SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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Extracellular vesicles and HIV-associated neurocognitive disorders: Implications in neuropathogenesis and disease diagnosis

2021

Extracellular vesicles are heterogeneous cell-derived membranous structures of nanometer size that carry diverse cargoes including nucleic acids, proteins, and lipids. Their secretion into the extracellular space and delivery of their...

The catastrophic HPV/HIV dual viral oncogenomics in concert with dysregulated alternative splicing in cervical cancer

2021

Cervical cancer is a public health problem and has devastating effects in low-to-middle-income countries (LTMICs) such as the sub-Saharan African (SSA) countries. Infection by the human papillomavirus (HPV) is the...

Cognitive differences between men and women with HIV: A systematic review and meta-analysis

2021

Objective: Although many studies report that women with HIV (WWH) are more vulnerable to cognitive impairment than men with HIV (MWH), this trend is not described consistently in the literature. In...

Frailty: The current challenge for aging people with HIV

2021

PURPOSE OF REVIEW: Older adults account for the majority of people with HIV (PWH) in high-income countries and have increasingly complex clinical profiles related to premature aging. Frailty is an...

Effects of undernutrition on mortality and morbidity among adults living with HIV in sub-Saharan Africa: A systematic review and meta-analysis

2021

BACKGROUND: Undernutrition is one of the most common problems among people living with HIV, contributing to premature death and the development of comorbidities within this population. In Sub-Saharan Africa (SSA),...

Worldwide relative smoking prevalence among people living with and without HIV

2021

Objective and design: People living with HIV (PLH) suffer disproportionately from the chronic diseases exacerbated by smoking tobacco. We performed a systematic review and meta-analysis to establish the relative prevalence of...

Exploring sustainability in the era of differentiated HIV service delivery in Sub-Saharan Africa: A systematic review

2021

INTRODUCTION: The World Health Organization recommends differentiated service delivery (DSD) to support resource-limited health systems in providing patient-centered HIV care. DSD offers alternative care models to clinic-based care for people...

Cabotegravir-Rilpivirine: The first complete long-acting injectable regimen for the treatment of HIV-1 infection

2021

OBJECTIVE: To review the efficacy and safety of cabotegravir (CAB) with rilpivirine (RPV) in the treatment of HIV-1 infection. DATA SOURCES: A literature search was performed using PubMed and Google...

Prevalence of cardiometabolic syndrome in HIV-infected persons: A systematic review

2021

Introduction: HIV infected persons are twofold likely to experience a heart attack, stroke, and other forms of Cardiometabolic Syndrome (CMetS). Methods: Electronic searches of databases (MEDLINE and Google Scholar) were queried for...

A systematic review of magnetic resonance imaging studies in perinatally HIV-infected individuals

2021

Over the past few years, neuroimaging studies have been performed in young adults with perinatally acquired HIV (PHIV) to study the impact of HIV infection on the central nervous system...

Kidney transplantation in HIV-positive patients: Current practice and management strategies

2021

BACKGROUND: HIV-positive patients had been successfully transplanted for the last 15 y and the donor pool had successfully been expanded to also include HIV-positive donors. METHODS: We aimed to evaluate...

Exploring the social impacts of the COVID-19 pandemic on people living with HIV (PLHIV): A scoping review

2021

Understanding the clinical impact of COVID-19 has been central to emerging research in the HIV field, but in focusing on the biomedical, researchers must not overlook the socially embedded nature...

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