SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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Undetectable = Untransmittable: A cross-population systematic review and meta-analysis on awareness and acceptance

2025

The Undetectable = Untransmittable (U=U) message is a cornerstone of HIV-related public health communication, yet global levels of awareness and acceptance remain unclear across key populations. This study aimed to...

Comparative safety of B/F/TAF versus other antiretroviral therapy regimens for treatment-naïve people with HIV-1: A systematic literature review and network meta-analysis

2025

Aim: Bictegravir, emtricitabine and tenofovir alafenamide (B/F/TAF) is a single-tablet regimen approved for the treatment of HIV-1 in treatment-naive (TN) and virologically suppressed people with HIV-1 (PWH). While the efficacy of...

Analysis of the effect of the COVID-19 pandemic on syphilis in susceptible populations: Me who have sex with men, people living with HIV, and patients with gestational and congenital syphilis—A narrative review

2025

The COVID-19 pandemic triggered a public health crisis that significantly impacted sexually transmitted infections (STIs), particularly syphilis. However, data on syphilis incidence during the pandemic remains inconsistent globally. Key groups...

Deep vein thrombosis in adults with HIV: A systematic review and meta-analysis of prevalence and risk factors

2025

Deep vein thrombosis (DVT) is a preventable yet serious complication among people living with human immunodeficiency virus (PLWH), attributed to hypercoagulability, low CD4+ counts, and antiretroviral therapy. Despite the high...

Possible prevention of neurodevelopmental consequences of vertical HIV transmission in early childhood? A systematic review

2025

BACKGROUND: Children infected with the Human Immunodeficiency Virus (HIV) exhibit the lowest neurodevelopmental scores. Mother-to-child-transmission prevention include perinatally and early antiretroviral therapy (ART) although long-term effects of in utero exposure...

Impact of COVID-19 on utilization of healthcare services among people living with HIV (PLHIV): A systematic review

2025

Background and Objectives: People living with HIV/AIDS have been impacted notably by the COVID-19 pandemic in diverse dimensions. Although some impacts of COVID-19 on PLHIV have been well documented, there...

Factors affecting poor prognosis of COVID-19 in people living with human immunodeficiency virus: A systematic review and meta-analysis of co-infection

2025

Objectives: This study aims to assess the correlation between clinical features and mortality in human immunodeficiency virus (HIV)-infected individuals with COVID-19. Methods: A systematic literature search was conducted for cohort, cross-sectional, and...

Causes of hospitalisation among people living with HIV worldwide, 2014-23: A systematic review and meta-analysis

2025

Background: Despite improved access to antiretroviral therapy (ART), HIV-related morbidity and mortality remain high. A previous review (2007-14) found that AIDS-related illnesses were the leading causes of hospitalisations. We aimed to...

Preventing unintended pregnancies and HIV through self-care interventions in east and southern Africa: Findings from a structured review

2025

OBJECTIVE: To identify promising interventions targeting young people in East and Southern Africa through self-care practices, with a focus on prevention of unintended pregnancies and HIV and develop four evidence-based...

Technology-based HIV prevention interventions for men who have sex with men: Systematic review and meta-analysis

2025

BACKGROUND: There remain unmet HIV prevention needs in China, particularly among gay, bisexual, and other men who have sex with men. Technology-based interventions are increasingly used in HIV prevention worldwide....

Technology-assisted interventions in the delivery of HIV prevention, care, and treatment services in sub-Saharan Africa: Scoping review

2025

BACKGROUND: Sub-Saharan Africa (SSA) accounts for up to 67% of the global HIV burden yet grapples with health system challenges like distant health facilities, low doctor-to-patient ratio, and poor or...

Prevalence of and risk factors for suicidal ideation among perinatal women with HIV infection: A systematic review, meta-analysis, and meta-regression

2025

Background The prevalence of suicidal ideation (SI) among HIV-positive pregnant women is a complex issue influenced by multiple risk factors. By addressing these risk factors and focusing on vulnerable regions,...

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