SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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Efavirenz versus protease inhibitors in patients with HIV: A systematic review and meta-analysis

2021

Efavirenz- and protease inhibitor (PI)-based regimens remain viable options across the globe. We conducted a meta-analysis to compare the effectiveness of efavirenz-based regimens relative to PI-based regimens. EMBASE, PubMed, Cochrane,...

Change in condom use in populations newly aware of HIV diagnosis in the United States and Canada: A systematic review and meta-analysis

2021

HIV-infected individuals “aware” of their infection are more likely to use condoms, compared to HIV-infected “unaware” persons. To quantify this likelihood, we undertook a systematic review and meta-analysis of U.S....

Prevalence of nontuberculous mycobacterium infections versus tuberculosis among autopsied HIV patients in sub-Saharan Africa: A systematic review and meta-analysis

2021

In industrialized countries, Mycobacterium avium complex and other nontuberculous mycobacteria (NTM) are major causes of opportunistic infection-related deaths in HIV patients. However, in resource-limited regions, data on NTM are scarce,...

What constitutes a palliative care need in people with serious illnesses across Africa? A mixed-methods systematic review of the concept and evidence

2021

BACKGROUND: Clarity on what constitutes a palliative care need is essential to ensure that health systems and clinical services deliver an appropriate response within Universal Health Coverage. AIM: To synthesise...

Effects of exercise interventions on aerobic capacity and health-related quality of life in people living with HIV/AIDS: Systematic review and network meta-analysis

2021

Objective: Exercise is a recommended component of care for people living with HIV/AIDS; however, it is unclear which type of exercise is most effective. The purpose of this study was to...

Structural interventions for HIV prevention and care among US men who have sex with men: A systematic review of evidence, gaps, and future priorities

2021

The preponderance of HIV interventions have been behavioral, targeting individual, dyadic, or group dynamics. However, structural-level interventions are required to decrease HIV transmission and increase engagement in care, especially for...

Influence of material deprivation on clinical outcomes among people living with HIV in high-income countries: A systematic review and meta-analysis

2021

Despite developments in HIV treatment and care, disparities persist with some not fully benefiting from improvements in the HIV care continuum. We conducted a systematic review to explore associations between...

Effectiveness of spatially targeted interventions for control of HIV, tuberculosis, leprosy and malaria: A systematic review

2021

BACKGROUND: As infectious diseases approach global elimination targets, spatial targeting is increasingly important to identify community hotspots of transmission and effectively target interventions. We aimed to synthesise relevant evidence to...

A systematic review of the effectiveness of non-health facility based care delivery of antiretroviral therapy for people living with HIV in sub-Saharan Africa measured by viral suppression, mortality and retention on ART

2021

BACKGROUND: Alternative models for sustainable antiretroviral treatment (ART) delivery are necessary to meet the increasing demand to maintain population-wide ART for all people living with HIV (PLHIV) in sub-Saharan Africa....

Prevalence and mortality due to COVID-19 in HIV co-infected population: A systematic review and meta-analysis

2021

INTRODUCTION: The coronavirus disease 2019 (COVID-19) was defined as a species of beta coronavirus causing atypical respiratory disease in humans. The COVID-19 pandemic has resulted in an unprecedented health and...

Immediate initiation of antiretroviral therapy (ART) after HIV diagnosis

2021

The benefits of beginning antiretroviral therapy (ART) soon after HIV diagnosis include improved health outcomes across a wide variety of settings as well as decreased long term healthcare costs. Generally,...

Age at menopause in women living with HIV: A systematic review

2021

Importance: With improved HIV care, more women living with HIV (WLWH) are aging and entering menopause. Understanding any increased risk conferred by a potentially earlier menopause transition is important for the...

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