SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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Prevalence of late HIV diagnosis and its impact on mortality: A comprehensive systematic review and meta-analysis

2025

Objectives: The late diagnosis of HIV infection plays a crucial role in accelerating the disease progression and increasing the risk of death in the HIV population. However, there remains no consensus...

The efficacy of Cotrimoxazole for the prevention of Pneumocystis jirovecii pneumonia among HIV-exposed and infected children: A systematic review

2025

BACKGROUND: HIV-related opportunistic infections like Pneumocystis jirovecii Pneumonia (PCP) remain a major contributor to child morbidity and mortality globally. PCP accounts for over 60% of AIDS in the first year...

Body image among people living with HIV: A systematic review and narrative synthesis

2025

OBJECTIVES: The aim of this systematic review was to analyse, synthesise and review existing research on body image among people living with HIV (PLWH). Specifically, the review investigated the relationship...

Efficacy, immunogenicity, and safety of the Novavax COVID-19 vaccine in immunocompromised patients: A targeted literature review

2025

Individuals who are immunocompromised (IIC) may have impaired infection prevention/resolution, potentially causing increased disease severity, complications, and healthcare-system strain. Exclusion of IIC from COVID-19 vaccine trials and limited real-world Novavax...

Global health initiatives and the combat of HIV/AIDS on the African continent: A scoping review

2025

The aim is to identify, in the literature, the influence of Global Health Initiatives (GHI) on the HIV combat in Africa. A scoping review was carried out in March 2023...

Assessing the impact of digital communication tools on oral PrEP adherence: A systematic review and meta-analysis

2025

This systematic review and meta-analysis evaluated the effect of digital communication tools (e.g., text message reminders) on improving daily oral HIV pre-exposure prophylaxis (PrEP) adherence. Searching PubMed, Embase, Web of...

What services, interventions and support are available for people with HIV in England to manage their overall health and wellbeing? A scoping review

2025

OBJECTIVES: The average age of a person living with HIV in high-income countries is increasing, as are rates of multimorbidity and frailty. To meet these needs, existing services must adapt....

Rapid start with bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) as initial treatment in people with human immunodeficiency virus-1 (HIV-1): A systematic literature review of clinical and patient-reported outcomes

2025

BACKGROUND: Treatment guidelines recommend rapid antiretroviral therapy (ART) initiation among eligible people with HIV to improve treatment outcomes and reduce HIV transmission. Bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF), an integrase strand transfer inhibitor-based...

Characterization and risk stratification of coronary artery disease in people living with HIV: A global systematic review

2025

Background Coronary artery disease (CAD) is a leading cause of mortality among people living with HIV (PLWH). Risk stratification remains inconsistent due to geographic disparities, ART-related metabolic effects, and overreliance...

Gut microbiota of sub-Saharan Africa infants exposed to antiretroviral therapy: Scoping review

2025

Background Antiretroviral (ARV) exposure influences the early-life gut microbiota in regions with high human immunodeficiency virus (HIV) burdens. Understanding how ARV drugs affect the infant gut microbiota is important for...

Prevalence of depression among people living with HIV on antiretroviral therapy in Africa: A systematic review and meta-analysis

2025

BACKGROUND: HIV is a global health issue, with the highest number of infected individuals found in sub-Saharan Africa. The coexistence of HIV with depression is a huge challenge. This study...

Predictors of anemia among HIV-infected children in Ethiopia: Systematic review and meta-analysis

2025

Anemia continues to be one of the common complications among HIV-infected children. In Ethiopia, though there is a systematic review and meta-analysis study on anemia among HIV-infected children, it only...

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