SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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Safety and efficacy of long-acting cabotegravir/rilpivirine versus standard oral antiretroviral therapy: A systematic review and meta-analysis

2025

Background In 2023, there were 39.9 million people living with HIV (PLWH) worldwide and 630 000 deaths related to HIV. New strategies are needed, and long-acting antiretrovirals (LAAs) are now widely...

Patient reported experiences in older adults living with

2025

Effective antiretroviral therapy has extended the life expectancy of people living with HIV and in Western countries, with 50% of individuals in Western countries now aged 50 or older. The...

Burden of depression among HIV caregivers in India: A systematic review and meta-analysis

2025

Caregivers of individuals living with HIV face significant mental health challenges, with depression being the most common. Despite global research highlighting this burden, studies specific to the Indian context are...

The prevalence of human papillomavirus (HPV) genotypes in the oral mucosae of HIV-positive individuals: A systematic review and meta-analysis

2025

Papillomaviruses are double-stranded DNA viruses, and it is essential to clarify their genotypic distribution for their effective prevention and clinical management. In this study, we aimed to evaluate the prevalence...

Exploring a rare association: Systematic review of hypercalcemia in nontuberculous mycobacterial infections

2025

Hypercalcemia represents a rare complication of nontuberculous Mycobacterium (NTM) infections, particularly in individuals with human immunodeficiency virus (HIV) positivity. This systematic review examines NTM infections associated with hypercalcemia, including the...

Growth patterns of HIV-exposed and -unexposed infants in African countries: A systematic review and meta-analysis

2025

Background/Objectives: The purpose of this study is to understand the prevalence and odds of poor growth patterns among HIV-exposed but uninfected (HEU) versus HIV-unexposed (HUU) infants in the era of antiretroviral...

The prevalence of dyslipidemia and its correlation with anti-retroviral therapy among people living with HIV in China: A systematic review and meta-analysis

2025

Background Dyslipidemia, a risk factor of cardiovascular diseases, was a long-term adverse event of anti-retroviral drugs. Efavirenz (EFV) and lopinavir/ritonavir (LPV/r) were recommended and the widely used antiretroviral drugs while...

Studies on cognitive performance among older people living with HIV in eastern Europe and central Asia: A scoping review

2025

BACKGROUND: Despite the growth of the population of older people living with HIV (PLWH), data on cognitive disorders among older PLWH, particularly in low- and middle-income countries, are scarce. These...

Sudden cardiac death in adults living with HIV: A systematic review

2025

Background People living with HIV (PLWH) have rising life expectancy, and robust evidence shows they are also at increased risk of cardiovascular disease. However, sudden cardiac death (SCD) for PLWH...

Prevalence and factors associated with HIV viral rebound in individuals on ART: A systematic review study

2025

BACKGROUND: Viral rebound (VR), the resurgence of detectable human immunodeficiency virus (HIV) viral loads (> 50 copies/mL) after suppression, remains a challenge for individuals on antiretroviral therapy (ART) in South...

Social determinants of adherence to antiretroviral therapy among adolescents and young people living with HIV: A scoping review

2025

OBJECTIVE: To map scientific evidence related to social determinants of adherence to antiretroviral therapy among adolescents and young people living with HIV. METHOD: Scoping review according to JBI methodology, carried...

Evolving landscape of economic evaluations of HIV pre-exposure prophylaxis and pre-exposure prophylaxis implementation strategies: A systematic review

2025

INTRODUCTION: Economic evaluations of HIV pre-exposure prophylaxis (PrEP) and associated implementation strategies guide evidence-based policies, programmes and resource allocation. Since 2015, there has been an evolution in PrEP modalities, implementation...

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