SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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Injection drug use, HIV/HCV, and related services in nonurban areas of the United States: A systematic review

2018

BACKGROUND: Injection drug use (IDU) in nonurban areas of the United States is a growing public health concern, but there has been no comprehensive assessment of existing research on injection-related...

Repurposing medications for use in treating HIV infection: A focus on valproic acid as a latency-reversing agent

2018

WHAT IS KNOWN AND OBJECTIVE: Combined antiretroviral therapy (ART) reduces human immunodeficiency virus type 1 (HIV-1) RNA plasma levels below the limit of detection. However, HIV-1 persists in latently infected...

Age-specific global prevalence of hepatitis B, hepatitis C, HIV, and tuberculosis among incarcerated people: A systematic review

2018

PURPOSE: This study aims to compare the global prevalence of hepatitis B, hepatitis C, HIV, and tuberculosis in incarcerated adolescents and young adults (AYAs) and older prisoners. METHODS: This study...

Determinants of HIV incidence disparities among young and older men who have sex with men in the United States

2018

This study sought to determine why young men who have sex with men (MSM) have higher HIV incidence rates than older MSM in the United States. We developed hypotheses that...

Prevalence of Cryptosporidium, microsporidia and Isospora infection in HIV-infected people: A global systematic review and meta-analysis

2018

BACKGROUND: Diarrhea caused by opportunistic intestinal protozoa is a common problem in HIV infection. We aimed to establish the prevalence of Cryptosporidium, misrosporidia, and Isospora in HIV-infected people using a...

The CCR5-Delta32 genetic polymorphism and HIV-1 infection susceptibility: A meta-analysis

2018

The CC chemokine receptor 5 (CCR5) is a chemokine receptor which is widely expressed in several immune cells involved in the inflammatory responses. Previous published studies revealed the relation of...

Tuberculosis-human immunodeficiency virus (HIV) co-infection in Ethiopia: A systematic review and meta-analysis

2018

BACKGROUND: Human Immunodeficiency Virus (HIV) and Tuberculosis (TB) are the double burden diseases of the world. The African continent takes a great share of TB-HIV cases worldwide. This study was...

Assessing the efficacy of lopinavir/ritonavir-based preferred and alternative second-line regimens in HIV-infected patients: A meta-analysis of key evidence to support WHO recommendations

2018

Background: Nucleoside reverse transcriptase inhibitors (NRTIs) and non-NRTIs (NNRTIs) with boosted protease inhibitors are included in standardized first-line and second-line regimens. Recent World Health Organization (WHO) guidelines recommend a boosted...

Histoplasma capsulatum antigen detection tests as an essential diagnostic tool for patients with advanced HIV disease in low and middle income countries: A systematic review of diagnostic accuracy studies

2018

INTRODUCTION: Disseminated histoplasmosis, a disease that often resembles and is mistaken for tuberculosis, is a major cause of death in patients with advanced HIV disease. Histoplasma antigen detection tests are...

Statin use and all-cause mortality in people living with HIV: A systematic review and meta-analysis

2018

BACKGROUND: It is unknown whether statin use among people living with HIV results in a reduction in all-cause mortality. We aimed to evaluate the effect of statin use on all-cause...

A meta-analysis of effectiveness of interventions to improve adherence in pregnant women receiving antiretroviral therapy in sub-Saharan Africa

2018

OBJECTIVE: We evaluated the effectiveness of interventions aimed at improving antiretroviral therapy (ART) adherence during pregnancy in sub-Saharan Africa. METHODS: For this meta-analysis, the following databases were searched: MEDLINE Complete,...

Strategies for improving the lives of US women aged 40 and above living with HIV/AIDS: An evidence map

2018

BACKGROUND: While in its early years the HIV epidemic affected primarily the male and the young, nowadays, the population living with HIV/AIDS is approximately 24% women, and its age composition...

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