SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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INSTIs-centered antiviral regimens for first-line treatment of HIV/AIDS: A network meta-analysis and cost-effectiveness analysis

2025

OBJECTIVE: This study evaluates the efficacy, safety, and cost-effectiveness of INSTI-based antiretroviral regimens compared to the national standard first-line treatment EFV/3TC/TDF for HIV/AIDS in China. The aim is to guide...

Prevalence of chronic kidney diseases among people living with HIV in Ethiopia: A systematic review and meta-analysis

2025

Background Chronic kidney disease (CKD) is a common condition among people living with HIV worldwide, but it is more common in patients from Africa. Both opportunistic infections and chronic illnesses...

The effectiveness of monetary incentives in improving viral suppression, treatment adherence, and retention in care among the general population of people living with HIV: A systematic review and meta-analysis

2025

Background Achieving and maintaining viral suppression and optimal adherence to antiretroviral therapy are crucial for improving health outcomes in general population of people living with HIV. This study aimed to...

Prevalence of hepatitis B virus infection and its associated factors in Ethiopia: A recent systematic review and meta-analysis

2025

BACKGROUND: Hepatitis B virus (HBV) is one of the most common causes of chronic liver disease and is a growing concern in low-income countries, including Ethiopia. Different studies have been...

Risk perception of human immunodeficiency virus, acquired immune deficiency syndrome, and reproductive health education among among junior and senior high school students: A scoping review

2025

This scoping review aims to identify studies that examine the existence and impact of HIV/AIDs education among high school-aged individuals in Ghana, underscoring the association of factors such as stigma...

Intermittent preventive treatment regimens for malaria in HIV-positive pregnant women: Systematic review and meta-analysis of clinical trials

2025

Background: The WHO recommended the use of intermittent preventive treatment (IPT) regimens for malaria in HIV-positive pregnant women living in endemic areas to prevent malaria-related perinatal complications. However, the high drug...

Syndemic interactions between HIV/AIDS, mental health conditions, and non-communicable diseases in sub-Saharan Africa: A scoping review of contributing factors

2025

INTRODUCTION: The syndemic framework provides a critical lens for understanding the complex interplay between HIV/AIDS, mental health (MH) conditions, and non-communicable diseases (NCDs) in Africa. This scoping review explores how...

Viral load suppression after enhanced adherence counseling among HIV patients on antiretroviral therapy (2019–2024): A systematic review and meta-analysis in East Africa

2025

Introduction Viral load suppression is essential for reducing human immunodeficiency virus (HIV) related morbidity and mortality. To eliminate the HIV epidemic and enhance adherence to antiretroviral therapy (ART) globally, the...

Integrating PrEP and sexual reproductive health services for adolescent girls and young women in South Africa: A scoping review

2025

Adolescent girls and young women (AGYW) in South Africa bear a disproportionate burden of the global HIV epidemic. Integrating PrEP into sexual and reproductive health (SRH) services offers a promising...

Polypharmacy in HIV: Rethinking what counts and why it matters

2025

Polypharmacy, the concurrent use of multiple medications, presents a growing challenge in HIV care as people living with HIV age and experience earlier onset of age-related co-morbidities. However, how polypharmacy...

Time to HIV viral rebound and frequency of post-treatment control after analytical interruption of antiretroviral therapy: An individual data-based meta-analysis of 24 prospective studies

2025

The only current strategy to test efficacy of novel interventions for sustained HIV control without antiretroviral therapy (ART) among people with HIV (PWH) is through an analytical treatment interruption (ATI)....

Evaluating predictive performance, validity, and applicability of machine learning models for predicting HIV treatment interruption: A systematic review

2025

Background HIV treatment interruption remains a significant barrier to achieving global HIV/AIDS control goals. Machine learning (ML) models offer potential for predicting treatment interruption by leveraging large clinical data. Understanding...

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