SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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Divergent structural and functional brain alterations in HIV-infected patients: A multimodal meta-analysis

2025

Neuroimaging studies have identified brain structural and functional alterations in HIV-infected patients; however, the results are inconsistent. This study aimed to characterize the effects of HIV infection on regional gray...

Factors related to loss to follow-up among people living with HIV: A systematic review

2025

Loss to follow-up (LTFU) among people living with HIV (PLHIV) is a concerning reality in various healthcare services and can occur at any stage of HIV care. LTFU can lead...

Exploring the impacts of high-intensity interval training (HIIT) in people living with HIV: A scoping review

2025

People with human immunodeficiency virus (PWH) face increased health risks beyond those directly linked to HIV infection, including reduced cardiorespiratory fitness (CRF), cardiovascular disease, and accelerated aging. Physical exercise, particularly...

Systematic review on the compliance of WHO guidelines in the management of patients with advanced HIV disease in Africa: The case of cryptococcal antigen screening

2025

BACKGROUND: The World Health Organization (WHO) recommended cryptococcal antigen (CrAg) screening for people presenting with advanced HIV disease (AHD) and for those with positive CrAg without evidence of meningitis to...

Thyroid disorders in patients with human immunodeficiency virus infection: A meta-analysis

2025

Background Thyroid disorders have significant clinical sequelae, including impaired growth in children, metabolic abnormalities, and impaired cognitive function. However, available studies on burden of thyroid diseases in people with human...

Success rates of endodontic treatment in HIV positive (HIV +) and non-HIV patients—A systematic review

2025

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Evaluating predictive performance, validity, and applicability of machine learning models for predicting HIV treatment interruption: A systematic review

2025

Background HIV treatment interruption remains a significant barrier to achieving global HIV/AIDS control goals. Machine learning (ML) models offer potential for predicting treatment interruption by leveraging large clinical data. Understanding...

Satisfaction with HIV/AIDS treatment and care services and its associated factors among adult people receiving antiretroviral therapy in Ethiopia: A systematic review and meta-analysis

2025

Objective To make healthcare programmes more patient-centred and efficient in light of limited resources, it is crucial to ensure patient satisfaction. There is limited information on the overall level of...

HIV associated motor neuron disease (MND): A case series with systematic review of literature

2025

Human immunodeficiency virus (HIV) associated motor neuron disease (MND) is very rare. HIV infection can cause an MND-like syndrome due to central nervous system (CNS) involvement de novo or during...

The association between HIV/AIDS, ototoxicity of its treatments, and occupational noise induced hearing loss: A narrative review mapping the existing literature and identifying research gaps

2025

Hearing loss remains a significant but underexplored health challenge in individuals with HIV/AIDS, particularly those exposed to occupational noise. The ototoxic effects of antiretroviral therapy (ART) and comorbid conditions like...

HIV infection and antiretroviral therapy impair liver function in people living with HIV: Systematic review and meta-analysis

2025

Background: The use of antiretroviral therapy (ART) has improved the lives of people living with HIV (PLWH). However, its use is associated with secondary complications, notably hepatotoxicity. This systematic review and...

Virologic Failure and Emergent Integrase Strand Transfer Inhibitor Drug Resistance With Long-Acting Cabotegravir for HIV Treatment: A Meta-analysis

2025

BACKGROUND: The long-acting injectable regimen of cabotegravir plus rilpivirine (CAB/RPV) emerged as an alternative to oral standard-of-care integrase strand transfer inhibitor (INSTI)-based regimens for individuals with adherence challenges or preference...

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