SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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Safety of oral tenofovir disoproxil fumarate-based HIV pre-exposure prophylaxis use in lactating HIV-uninfected women

2016

INTRODUCTION: In settings where HIV is prevalent in heterosexual populations, pregnancy and postpartum breastfeeding periods can be associated with substantial HIV acquisition risk. Pre-exposure prophylaxis (PrEP) with daily oral tenofovir...

Adverse effects of oral second-line antituberculosis drugs in children

2016

INTRODUCTION: Increasing numbers of children with drug-resistant tuberculosis are accessing second-line antituberculosis drugs; these are more toxic than first-line drugs. Little is known about the safety of new antituberculosis drugs...

The effect of HIV counselling and testing on HIV acquisition in sub-Saharan Africa: A systematic review

2016

OBJECTIVES: Annually, millions of people in sub-Saharan Africa (SSA) receive HIV counselling and testing (HCT), a service designed to inform persons of their HIV status and, if HIV uninfected, reduce...

Atazanavir and cardiovascular risk among human immunodeficiency virus-infected patients: A systematic review

2016

INTRODUCTION: Patients with human immunodeficiency virus (HIV) infection have an increased risk of cardiovascular disease (CVD). While viral suppression with antiretroviral therapy decreases CVD risk overall, several studies have suggested...

Pharmacologic and non-pharmacologic treatments for chronic pain in individuals with HIV: A systematic review

2016

Chronic pain occurs in as many as 85% of individuals with HIV and is associated with substantial functional impairment. Little guidance is available for HIV providers seeking to address their...

Pattern of infectious morbidity in HIV-exposed uninfected infants and children

2016

BACKGROUND: Almost 30% of children in Southern Africa are HIV exposed but uninfected (HEU) and experience exposures that could increase vulnerability to infectious diseases compared to HIV unexposed (HU) children....

What do we know about children living with HIV-infected or AIDS-ill adults in Sub-Saharan Africa? A systematic review of the literature

2016

Millions of children in Sub-Saharan Africa live with adults, often parents, who are HIV-infected or ill due to AIDS. These children experience social, emotional, and health vulnerabilities that overlap with,...

Health-information needs of HIV-positive adults in Latin America and the Caribbean: An integrative review of the literature

2016

An assessment of information needs is essential for care planning for patients living with chronic diseases such as human immunodeficiency virus (HIV). The extent to which these assessments have been...

Psychological health and HIV transmission among female sex workers: A systematic review and meta-analysis

2016

Current HIV prevention interventions for female sex workers (FSWs) have tended to target the cognitive factors in changing their behaviors, yet little attention has been paid to the psychological factors...

Viral suppression in adolescents on antiretroviral treatment: Review of the literature and critical appraisal of methodological challenges

2016

OBJECTIVE: Medication adherence is often sub-optimal for adolescents with HIV, and establishing correct weight-based antiretroviral therapy dosing is difficult, contributing to virological failure. This review aimed to determine the proportion...

What factors affect the health and well-being of lesbian, gay and bisexual Asian youth?

2016

Key take-home messages Some studies have found a relationship between sexual minority status and substance use among Asian youth and adults. However, other studies have found evidence of resilience among...

Is pre-exposure prophylaxis effective for preventing HIV infection in men who have sex with men?

2016

INTRODUCTION: Increasing rates of HIV infection remain of concern, especially for high-risk groups such as men who have sex with men. Oral pre-exposure prophylaxis has emerged as an alternative to...

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