SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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Systematic review of prevalence and predictors of frailty in individuals with human immunodeficiency virus

2016

OBJECTIVES: To describe the prevalence and predictors of frailty in individuals with the human immunodeficiency virus (HIV) using systematic review methodology. DESIGN: Review. SETTING: Community. PARTICIPANTS: Older adults with HIV....

A meta-analysis of HIV and heart rate variability in the era of antiretroviral therapy

2016

BACKGROUND: Heart rate variability (HRV) has been used to assess autonomic dysfunction since the beginning of the HIV epidemic. Although autonomic failure was commonly detected in HIV and AIDS patients...

Socioeconomic differences in HIV/AIDS mortality in South Africa

2016

OBJECTIVES: To quantify socioeconomic differences in the risk of HIV/AIDS mortality in South Africa for different measures of socioeconomic status. METHODS: Systematic literature search in Web of Knowledge and PubMed....

Evaluation of health disparity in bacterial vaginosis and the implications for HIV-1 acquisition in African American women

2016

There is a health disparity for both bacterial vaginosis (BV) and human immunodeficiency virus type 1 (HIV-1) infection in African American women that may be linked. The evidence that BV...

Prevalence of non-HIV cancer risk factors in persons living with HIV/AIDS: A meta-analysis

2016

OBJECTIVE: The burden of cancer among persons living with HIV/AIDS (PLWHA) is substantial and increasing. We assessed the prevalence of modifiable cancer risk factors among adult PLWHA in Western high-income...

Hepatitis C reinfection after successful treatment

2016

Key take-home messages HCV reinfection rates vary widely. Reinfection depends on the extent to which an individual engages in high risk activities after having achieved sustained virologic response through treatment....

Can the UNAIDS 90-90-90 target be achieved? A systematic analysis of national HIV treatment cascades

2016

BACKGROUND: In 2014, the Joint United Nations Programme on HIV and AIDS (UNAIDS) and partners set the ’90-90-90 targets’; aiming to diagnose 90% of all HIV positive people, provide antiretroviral...

A comprehensive review of the barriers and promoters health workers experience in delivering prevention of vertical transmission of HIV services in sub-Saharan Africa

2016

Despite significant biomedical and policy advances, 199,000 infants and young children in sub-Saharan Africa (SSA) became infected with HIV in 2013, indicating challenges to implementation of these advances. To understand...

Increased risk of group B streptococcus invasive infection in HIV-exposed but uninfected infants: A review of the evidence and possible mechanisms

2016

Group B Streptococcus (GBS) is a major cause of neonatal sepsis and mortality worldwide. Studies from both developed and developing countries have shown that HIV-exposed but uninfected (HEU) infants are...

Toward the sustainability of health interventions implemented in sub-Saharan Africa: A systematic review and conceptual framework

2016

BACKGROUND: Sub-Saharan Africa (SSA) is facing a double burden of disease with a rising prevalence of non-communicable diseases (NCDs) while the burden of communicable diseases (CDs) remains high. Despite these...

Burden of pneumocystis pneumonia in HIV-infected adults in sub-Saharan Africa: A systematic review and meta-analysis

2016

BACKGROUND: Seroprevalence data and clinical studies in children suggest that the burden of pneumocystis pneumonia (PCP) in Africa may be underestimated. We performed a systematic review to determine the prevalence...

Barriers and facilitators of interventions for improving antiretroviral therapy adherence: A systematic review of global qualitative evidence

2016

INTRODUCTION: Qualitative research on antiretroviral therapy (ART) adherence interventions can provide a deeper understanding of intervention facilitators and barriers. This systematic review aims to synthesize qualitative evidence of interventions for...

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