SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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Evaluating equity reporting within systematic reviews of pre-exposure prophylaxis (PrEP)

2025

BACKGROUND: Pre-exposure prophylaxis (PrEP) is a medicine that can reduce HIV transmission. Given the disproportionate impact of HIV on minority communities, health equity is an important consideration in PrEP research....

Complications due to HIV in patients undergoing total joint arthroplasty: A systematic review and meta-analysis

2025

Background: HIV infection in patients undergoing Total joint arthroplasty (TJA) results in adverse postoperative outcomes. However, there are uncertain data regarding the extent of involvement of HIV in TJA and the...

HIV and the gut microbiome: Future research hotspots and trends

2025

BACKGROUND: The use of highly active antiretroviral therapy has transformed AIDS into a chronic infectious disease, but issues of chronic inflammation and immune system activation persist. Modulating the gut microbiome...

HIV pre-exposure prophylaxis (PrEP) use among PrEP-eligible men who have sex with men: A systematic review and meta-analysis

2025

Objective: Scaling up pre-exposure prophylaxis (PrEP) is critical to combating the AIDS epidemic, especially among PrEP-eligible men who have sex with men (MSM). This study summarizes the global proportion of PrEP-eligible...

Kidney dysfunction and associated factors among adults living with human immuno-deficiency virus in Africa: A systematic review and meta-analysis

2025

Background Kidney dysfunction among adults living with Human Immuno-Deficiency Virus (HIV) increases the risk of drug-related side effects, acute kidney injury, hospitalization, and progression to end-stage kidney disease. In developing...

Global, regional, and national estimates of hepatitis C virus (HCV) infection incidence among people who inject drugs and number of new annual HCV infections attributable to injecting drug use: A multi-stage analysis

2025

Background: Measuring progress towards the WHO 2030 target for hepatitis C virus (HCV) elimination among people who inject drugs (PWID)-an incidence of two or fewer infections per 100 person-years-has been challenging...

Hiding in plain sight: Highlighting the research gap on access to HIV and other sexual health services for underrepresented gay men in developed Western countries—Insights from a scoping review with a focus on Arab men

2024

BACKGROUND: Strategies pertaining to HIV and sexual health for gay, bisexual, and other men who have sex with men (GBMSM) have shifted focus towards underrepresented subgroups within some developed Western...

HIV-1 drug resistance detected by next-generation sequencing among ART-naive individuals: A systematic review and meta-analysis

2024

Background: There are an increasing number of articles focused on the prevalence and clinical impact of pretreatment HIV drug resistance (PDR) detected by Sanger sequencing (SGS). PDR may contribute to...

Prevalence of emergent dolutegravir resistance mutations in people living with HIV: A rapid scoping review

2024

BACKGROUND: Dolutegravir (DTG) is a cornerstone of global antiretroviral (ARV) therapy (ART) due to its high efficacy and favorable tolerability. However, limited data exist regarding the risk of emergent integrase...

Multimodal approach to neurocognitive function in people living with HIV in the cART era: A comprehensive review

2024

Combination antiretroviral treatment (cART) has revolutionized the management of human immunodeficiency virus (HIV) and has markedly improved the disease burden and life expectancy of people living with HIV. HIV enters...

Analysis and mapping of global research publications on point-of-care testing for infectious diseases

2024

RATIONALE: This study presents the first comprehensive analysis and mapping of scientific research on point-of-care testing (POCT) in infectious diseases, filling a gap in understanding the evolving landscape of this...

Low clinical impact of HIV drug resistance mutations in oral pre-exposure prophylaxis: A systematic review and meta-analysis

2024

Introduction Despite the widespread use of pre-exposure prophylaxis (PrEP) in preventing human immunodeficiency virus (HIV) transmission, scant information on HIV drug resistance mutations (DRMs) has been gathered over the past...

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