SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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HIV: Associated transmission risks in older adults – An integrative review of the literature

2004

Recent evidence suggests that transmission of human immunodeficiency virus (HIV) is increasing among late middle-aged and older adults (50 years of age or older). However, research studies explaining the unique...

Changes in the human immunodeficiency virus V3 region that correspond with disease progression: A meta-analysis

2004

In order to determine the changes in the human immunodeficiency virus type-1 (HIV-1) envelope that corresponds with disease progression, a meta-analysis of viral forms was performed using HIV-1 sequences obtained...

HIV prevention interventions in adolescent girls: What is the state of the science?

2004

BACKGROUND AND PURPOSE: Adolescent girls now represent one of the fastest growing groups of persons infected with HIV. A systematic review was undertaken to identify and critique the most scientifically...

Cytotoxic T-lymphocyte responses to canarypox vector-based HIV vaccines in HIV-seronegative individuals: A meta-analysis of published studies

2004

PURPOSE: A successful prophylactic HIV vaccine will probably require neutralizing antibodies and vigorous CTL (CD8+ T-cytotoxic lymphocyte) responses. Canarypox vector-based HIV vaccines (ALVAC-HIV) have been gaining momentum as promising HIV...

Cost-effectiveness of antenatal HIV-testing: Reviewing its pharmaceutical and methodological aspects

2004

This paper reviews the pharmacoeconomic aspects of antenatal testing for HIV. HIV is a retrovirus which is transmitted among humans through sexual contact, infected blood or blood products (needle sharing...

Pharmacologic perspectives for once-daily antiretroviral therapy

2004

OBJECTIVE: To contrast available once-daily antiretroviral agents and combinations of these agents from a clinical pharmacologic viewpoint. DATA SOURCES: Data were extracted from publications and major HIV conference proceedings cited...

Changes in hematologic parameters and efficacy of thymidine analogue-based, highly active antiretroviral therapy: A meta-analysis of six prospective, randomized, comparative studies

2004

Background: Hematologic changes that occur with HIV infection and antiretroviral therapy may impact the quality of life of patients and have been associated with morbidity and mortality. The management of...

Improving services for disadvantaged childbearing women

2004

BACKGROUND: Tackling health inequalities is high on the political agenda of the Labour government. The government wants to reduce inequalities through policies based on evidence, the health of childbearing women...

Population-based interventions for reducing sexually transmitted infections, including HIV infection

2004

BACKGROUND: Sexually transmitted infections (STI) are common in developing countries. The World Health Organisation (WHO) estimates that in 1999, 340 million new cases of syphilis, gonorrhoea, chlamydial infection and trichomoniasis...

A systematic review of the clinical significance of pulmonary Mycobacterium kansasii isolates in HIV infection

2004

Guidelines recommend treating HIV-infected patients with pulmonary Mycobacterium kansasii infection only in the presence of multiple positive cultures and clinical and radiographic abnormalities. Some authors suggest a single positive culture...

Efficacy of selected treatments of HIV wasting: A systematic review and meta-analysis

2004

PURPOSE: To assess the efficacy of recombinant human growth hormone (rhGH), testosterone, and anabolic steroids in the treatment of HIV wasting. METHODS: A systematic review and meta-analysis of studies published...

Terbinafine in the treatment of onychomycosis: A review of its efficacy in high-risk populations and in patients with nondermatophyte infections

2004

BACKGROUND: The prevalence of onychomycosis is higher in certain high-risk populations, such as the immunocompromised, diabetics and human immunodeficiency virus (HIV)-positive patients. These patients can also develop onychomycosis due to...

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