SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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Culturally competent HIV prevention for African, Caribbean, and Black communities and Indigenous Peoples

2026

Key take-home messages Developing culturally sensitive approaches and materials helps ensure HIV prevention interventions are relevant, acceptable, and responsive to the needs of the intended population groups. Close collaboration with...

Effects of digital health interventions to promote safer sex behaviors among youth: Systematic review and Bayesian network meta-analysis

2026

Background Youth aged 15–24 years carry a disproportionate HIV/sexually transmitted infections (STIs) burden. In recent years, different modalities of digital health interventions (DHIs) have been explored to promote safer sex behaviors...

Virus-directed CAR immunotherapies for chronic HBV and HIV: A systematic synthesis of preclinical and early clinical evidences

2026

BACKGROUND: Chronic hepatitis B virus (HBV) and human immunodeficiency virus (HIV) infections are among the most important global health issues. Virus-directed CAR-T and CAR-NK are promising strategies capable of targeting...

Understanding the implementation of patient navigation for adults living with HIV: A scoping review of components, equity considerations and lessons learned

2026

Background People living with HIV navigate complex medical and social challenges that impact engagement in care, including stigma, poverty and systemic inequities. Patient navigation has emerged as a promising approach...

Physical activity counseling for people living with HIV: A scoping review

2026

Objective: To explore evidence on physical activity counseling for people living with HIV (PLHIV). Methods: Searches covered earliest records in PubMed (1946), Embase (1947), Web of Science (1900), Scopus (1788), and LILACS...

Role of pharmacists in HIV prophylaxis: A scoping review of pharmacists’ services, interventions and outcomes

2026

INTRODUCTION: HIV remains a major global public health challenge, with nearly 1.3 million new HIV acquisitions annually. Despite the effectiveness of pre-exposure (PrEP) and post-exposure prophylaxis (PEP), barriers to access,...

Incidence of severe immune-related adverse reactions in patients with HIV and cancer receiving immune checkpoint inhibitors: A systematic review and meta-analysis

2026

Background With the continuous advancement of various treatment modalities, such as antiretroviral therapy, the life expectancy of people living with HIV (PLWH) is approaching that of the general population. Consequently, the...

Unmet need for family planning among reproductive-age women living with HIV in Africa: A systematic review and meta-analysis

2026

Background Unmet need for family planning remains a major challenge worldwide, particularly in Africa, contributing to unintended pregnancies, unsafe abortions, and increased maternal morbidity and mortality. Reducing the unmet need...

Missing assent: A global systematic review of ethical practices in HIV research with men who have sex with men (MSM) under 18

2026

Background Ethical safeguards are critical in HIV research involving minors, especially vulnerable groups such as men who have sex with men (MSM) under 18 years. This systematic review explores how informed...

Worldwide changes in HIV-related stigma among people living with HIV: A cross-temporal meta-analysis and systematic review

2026

Background: HIV-related stigma among people living with HIV has emerged as a growing public health concern, yet limited longitudinal data are available to characterize its evolution over time. In this study,...

Age-specific distribution of cervical precancer and cancer among women living with HIV across seven countries: A systematic review and an individual patient data meta-analysis

2026

Background Women living with HIV have an elevated risk for cervical cancer, present earlier, and have more recurrent human papillomavirus (HPV) infections compared with women without HIV. To update WHO recommendations...

Commonality and co-occurrence of discrete strategies within implementation strategy bundles: Findings from the Living Database of HIV Implementation Science systematic review, 2014-2021

2026

Background HIV services and innovations are delivered through implementation strategy bundles that are often complex, comprising numerous discrete strategies. Systematically characterizing the use patterns of discrete strategies may inform strategy...

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