Prevalence of different HIV-1 subtypes in sexual transmission in China: A systematic review and meta-analysis


Sexual transmission has become the primary route of HIV transmission in China. Therefore, a comprehensive overview of HIV-1 subtype distribution is necessary for the prevention and control of the HIV epidemic. The present study aimed to provide a comprehensive prevalence estimate of different HIV-1 subtypes in sexual transmission in China. We conducted a systematic literature review for studies of HIV-1 subtypes in English and Chinese through several databases. Eligible articles were screened and selected by two authors independently. Random-effects model were applied to calculate the pooled prevalence of different HIV-1 subtypes, and subgroup analyses examined prevalence estimates across time, locations, and populations. A total of 130 eligible studies were identified, including 18 752 successfully genotyped samples. The pooled prevalence of CRF01_AE, subtype B, CRF07_BC, CRF08_BC, and subtype C were 44.54% (95% CI 40.81-48.30), 18.31% (95% CI 14.71-22.17), 16.45% (95% CI 13.82-19.25), 2.55% (95% CI 1.56-3.73), 0.37% (95% CI 0.11-0.72), respectively. The prevalence of subtype B in sexual transmission decreased, while the prevalence of CRF01_AE and CRF07_BC in sexual transmission, and CRF08_BC in heterosexual transmission increased. There is significant variation in HIV-1 subtype distribution between regions. The distribution of HIV-1 subtypes and circulating recombinant forms have changed significantly. The high genetic variability of HIV-1 poses a significant challenge for disease control and surveillance in China.


Yuan R, Cheng H, Chen LS, Zhang X, Wang B.




  • Epidemiology and Determinants of Health
    • Epidemiology
  • Population(s)
    • General HIV+ population


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