Role of SDF-1 3’A polymorphism in HIV-1 disease progression: A systematic review and meta-analysis

BACKGROUND: Chemokine stromal cell-derived factor 1(SDF-1) 3’A polymorphism has been reported to influence HIV-1 disease pathogenesis and progression, but the results remain controversial. OBJECTIVES: A meta-analysis was carried out to evaluate their association. METHODS: Comprehensive literature search of Pubmed, Web of Science and China National Knowledge Infrastructure was conducted. The strength of association between SDF-1 3’A polymorphism and HIV-1 progression was evaluated using the pooled ORs and 95%CIs calculated under different comparison models. Subgroup analyses, heterogeneity, Galbraith plot analyses and test for publication bias were also carried out. RESULTS: Our result showed that when compared with the typical progressors, the GA+AA and GA genotype of SDF-1 3’A polymorphism was found positively associated with the long-term non-progressors (LTNP) in the Caucasian HIV-1 infectors (GA+AA vs. GG, OR=1.49, 95% CI: 1.02-2.18, p=0.040; GA vs. GG, OR=1.58, 95% CI: 1.06-2.35, p=0.024), while AA genotype was found significantly higher in Asian LTNPs (AA vs. GG+GA, OR=3.32, 95% CI: 1.25-8.85, p=0.016). CONCLUSIONS: Our result suggested that HIV-1 infectors with SDF-1 3’A polymorphism have a higher chance of developing late AIDS than infectors with the SDF-1 GG genotype

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