The efficacy of post-exposure prophylaxis (PEP) for HIV


Key take-home messages
  • PEP initiated soon after exposure can reduce the risk of HIV seroconversion after occupational and non-occupational exposures, provided adherence to medications is sufficient.
  • Evidence suggests that individuals prescribed tenofovir-based two- or three-drug regimens are more likely to complete a course of PEP and have lower discontinuation rates due to adverse events compared to zidovudine-based regimens.
  • Guidelines from Canada and the U.S. most commonly recommend a 28-day regimen of oral tenofovir disoproxil fumarate/emtricitabine (300mg/200mg) once daily plus raltegravir (400mg) twice daily for adults and adolescents as a preferred first-line regimen for both occupational and non-occupational PEP.
  • The World Health Organization makes recommendations for PEP regimens based on differences in accessibility between high- and low-income settings.


The Ontario HIV Treatment Network: Rapid Response Service




  • Population(s)
    • Men who have sex with men
    • Children or Youth (less than 18 years old)
    • General HIV+ population
  • Prevention
    • Biomedical interventions


Abstract/Full paper

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