Use of antiretroviral therapy during pregnancy and adverse birth outcomes among women living with HIV-1 in low- and middle-income countries: A systematic review


BACKGROUND: Worldwide, nearly 18 million women of reproductive age are living with HIV-1. Although increased access to antiretroviral therapy (ART) during pregnancy has significantly reduced HIV-1 mother-to-child transmission (MTCT), a similarly robust reduction in preterm birth (PTB) and low birthweight (LBW) among infants born to women living with HIV has not been observed. This study was designed to identify associations between classes of ART regimens and risk of PTB or LBW. SETTING: Low- and middle-income countries. METHODS: We conducted a systematic review of randomized and observational studies that assessed the effect of ART regimen on the risk of PTB (


Saleska JL, Turner AN, Maierhofer C, Clark J, Kwiek JJ




  • Population(s)
    • Women
    • Children or Youth (less than 18 years old)
    • General HIV+ population
  • Engagement and Care Cascade
    • Treatment
  • Prevention
    • Biomedical interventions
  • Health Systems
    • Delivery arrangements


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