SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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Prevalence and risk factors for oropharyngeal, esophageal, and oral candidiasis in HIV-positive individuals: A systematic review and meta-analysis

2026

Background: Oral, oropharyngeal, and esophageal candidiasis are common forms of mucosal candidiasis (MC) in people living with human immunodeficiency virus/acquired immunodeficiency syndrome (PLWHA). Despite differences in infection sites, oral, oropharyngeal, and...

Choosing between dual and three-drug antiretroviral therapy in aging and comorbid people with HIV: A narrative review

2026

The widespread use of combination antiretroviral therapy has transformed HIV infection into a chronic condition, with life expectancy of people with HIV (PWH) approaching that of the general population when...

The global re-emergence of syphilis and antimicrobial resistance among men who have sex with men (MSM), people living with HIV (PLWH), and newborns: A narrative review

2026

Syphilis incidence continues to rise substantially among men who have sex with men (MSM), people living with HIV (PLWH), newborns, and women of reproductive age, despite preventive measures and available...

Effectiveness of HIV status disclosure interventions among children and adolescents in low and middle-income countries: A systematic review

2026

BACKGROUND: Appropriate pediatric HIV status disclosure remains a public health challenge in low- and middle-income countries (LMICs). This review aims to describe the existing pediatric HIV disclosure interventions in LMICs...

Can ChatGPT match physicians in the diagnosis, triage, management and prevention of infectious diseases? A scoping review

2026

INTRODUCTION: The global burden of infectious diseases (ID), combined with a shortage of ID specialists, continues to challenge healthcare systems worldwide. Artificial intelligence (AI), particularly large language models such as...

Barriers and facilitators to STI and HIV testing among African and Caribbean heritage communities in high-income countries mapped to the behaviour change wheel: A scoping review

2026

Background: African and Caribbean communities in high-income countries face disproportionate sexually transmitted infection (STI) risks. In the US, the gonorrhoea rate among non-Hispanic Blacks is 7.7 times greater than that among...

Dysregulated metabolism in people living with HIV in the modern ART-era: A systematic review of targeted metabolomics studies

2026

HIV remains a significant public health issue, with 1.3 million new infections and 630,000 deaths annually, and 40.8 million people living with HIV (PLHIV) globally in 2024. Although antiretroviral therapy...

Barriers and facilitators to oral HIV pre-exposure prophylaxis use in Australia: A scoping review comparing findings to Canada, New Zealand, and the United Kingdom

2026

Oral HIV pre-exposure prophylaxis (PrEP) is highly effective, yet various barriers limit its potential as a HIV prevention strategy. This scoping review aimed to identify and quantify determinants of oral...

Maternal-to-child-transmission of human immunodeficiency virus in maternal preterm premature rupture of the membranes: A systematic review

2026

Aim: Preterm premature rupture of membranes (PPROM) in the context of maternal human immunodeficiency virus (HIV) infection poses a significant clinical dilemma, as clinicians must balance the risks of prematurity with...

Facilitators and barriers to cervical cancer screening among women living with HIV: A systematic review of qualitative studies

2026

BACKGROUND: Evidence suggests that 58% of new cervical cancer cases worldwide occur among women living with HIV. However, compared with HIV-negative women, this population has significantly poorer access to healthcare...

Interventions to increase adherence to antiretroviral therapy in people living with HIV—what works? A systematic review and meta-analysis

2026

The Perceptions and Practicalities Approach (PaPA) is a recommended framework for designing medication adherence interventions. Little is known about the utility of the PaPA framework in improving antiretroviral therapy (ART)...

Disparities in awareness, willingness and uptake of biomedical HIV prevention among bisexual and gay men: A systematic review and meta-analysis

2026

INTRODUCTION: The field of HIV/STI prevention research has primarily focused on gay men, leaving bisexual men overshadowed in broader discussions on sexual minority men’s health. Although also at increased risk...

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