SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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Adolescents’ sexual health during the COVID-19 outbreak: A systematic review

2025

BACKGROUND AND AIMS: The COVID-19 pandemic has greatly disrupted adolescents’ access to sexual health services, resulting in a decline in their overall sexual well-being. This systematic review explored adolescent sexual...

Two-Spirit, gay, bisexual, transgender and queer (2SGBTQ) men’s suicidality in Canada: A scoping review

2025

Suicide is a leading cause of death in Canada, with men being three times more likely to die from suicide compared with the rest of the population. Among Canadian men,...

Doxycycline prophylaxis for the prevention of bacterial sexually transmitted infections (STIs): doxyPrEP and doxyPEP

2024

No abstract available

Immune responses to vaginal candidiasis in African women: A scoping review of cytokine profiles, T-cell activation, and gene expression

2025

Background Recent immunological studies of vaginal candidiasis in African populations have revealed complex host‒pathogen interactions with implications for therapeutic development and HIV acquisition risk. Objective This scoping review synthesized evidence...

Social and structural determinants of health influencing HIV risk and participation across the HIV care cascade

2025

Key take-home messages

Transitioning to adult HIV care: Challenges and evidence-based practices

2025

Key take-home messages

Real-world effectiveness and tolerability of dolutegravir and lamivudine 2-drug regimen in people living with HIV: Systematic literature review and meta-analysis

2025

Introduction Dolutegravir (DTG) + lamivudine (3TC) demonstrated high rates of virologic suppression (VS) and low rates of virologic failure (VF), discontinuation, and drug resistance in randomized trials. Real-world evidence can support treatment...

Impact of social determinants of health on cancer treatment referrals in patients living with HIV in the United States: A narrative review

2024

INTRODUCTION: This narrative review aims to identify and explore the social determinants that prevent people living with HIV (PWH) from accessing specialized cancer centers in the United States and compare...

Experiences and perceptions on antiretroviral therapy adherence and non-adherence: A scoping review of young people living with HIV in sub-Saharan Africa

2025

BACKGROUND: Young people in sub-Saharan Africa (SSA) shoulder a disproportionate burden of global HIV. We conducted a scoping review to map the research on the experiences and perceptions of young...

Aging and HIV: Recent findings in contributing factors

2025

Background: Aging among people living with HIV (PLWH) presents multifaceted challenges influenced by antiretroviral therapy (ART), chronic inflammation, viral coinfections, stigma, multimorbidity, and immunosuppression. Methods: This review synthesizes recent research...

The association between HIV/AIDS, ototoxicity of its treatments, and occupational noise induced hearing loss: A narrative review mapping the existing literature and identifying research gaps

2025

Hearing loss remains a significant but underexplored health challenge in individuals with HIV/AIDS, particularly those exposed to occupational noise. The ototoxic effects of antiretroviral therapy (ART) and comorbid conditions like...

Technology-assisted interventions in the delivery of HIV prevention, care, and treatment services in sub-Saharan Africa: Scoping review

2025

BACKGROUND: Sub-Saharan Africa (SSA) accounts for up to 67% of the global HIV burden yet grapples with health system challenges like distant health facilities, low doctor-to-patient ratio, and poor or...

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