SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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HIV risk and prevention among cisgender men who have sex with transgender women or transfeminine nonbinary people

2026

Key take-home messages

Syndemics and clinical impact of HIV and mental health conditions among people living with HIV: A systematic review and meta-analysis

2026

INTRODUCTION: People living with HIV (PLWH) may be exposed to harmful political, social, economic and environmental factors that exacerbate their risk of mental health conditions. Such factors can interact synergistically...

Experiences and outcomes of peer navigation and support interventions for adolescents on HIV treatment in sub-Saharan Africa: A qualitative evidence synthesis

2026

Adolescents living with HIV (ALHIV) face ongoing challenges with treatment adherence and engagement in care, resulting in lower viral suppression rates compared to adults. Peer navigation has shown promise in...

Understanding the implementation of patient navigation for adults living with HIV: A scoping review of components, equity considerations and lessons learned

2026

Background People living with HIV navigate complex medical and social challenges that impact engagement in care, including stigma, poverty and systemic inequities. Patient navigation has emerged as a promising approach...

The global epidemiology of injecting drug use, HIV, viral hepatitis and tuberculosis among people who are incarcerated: A multistage systematic review

2026

Background: This global systematic review assesses the prevalence of injecting drug use (IDU) and key infectious diseases (HIV, hepatitis C virus [HCV], tuberculosis and hepatitis B virus [HBV]) among people...

The emerging role of Interleukin-32 in HIV-associated cardiovascular comorbidities: A mini review

2026

With the widespread use of antiretroviral therapy (ART), the life expectancy of people living with HIV (PLWH) has significantly improved. However, the incidence of cardiovascular disease (CVD) in this population...

Risk of HIV transmission by healthcare workers—A systematic review

2026

BACKGROUND: Occupational HIV infection among healthcare workers (HCWs) has declined markedly in high-income countries as a result of improved infection prevention and control, safety-engineered devices, and the widespread availability of...

Alcohol use and the care continuum for HIV preexposure prophylaxis: An updated scoping review of research and interventions

2026

Rationale In 2007, WHO issued emergency recommendations on empiric treatment of sputum acid-fast bacillus (AFB) smear-negative patients with possible tuberculosis (TB) in HIV-prevalent areas, and called for operational research to...

A synthesis of dimensions of wellbeing among adolescents and young people living with HIV from sub-Saharan Africa for measurement in economic evaluation: A qualitative overview of reviews

2026

Background Adolescents and young people living with HIV (AYPLHIV) in sub-Saharan Africa (SSA) face intersecting structural and psychosocial challenges that compromise their wellbeing, yet these realities are poorly captured by...

Telomere length dynamics in adults living with HIV: A systematic review

2026

Background: HIV infection is associated with accelerated biological ageing, with telomere shortening serving as a key biomarker. Although numerous studies have investigated telomere dynamics in people living with HIV (PLWH),...

Effectiveness of empiric tuberculosis treatment for presumptive smear-negative pulmonary TB among people living with HIV, a systematic narrative review

2025

Introduction: Timely diagnosis and prompt initiation of treatment are crucial for the effective management of tuberculosis (TB), particularly in People living with HIV (PLHIV). A delay in diagnosing TB,in this special...

Effectiveness of pre-exposure prophylaxis (PrEP) in the prevention of human immunodeficiency virus (HIV): A systematic review of randomized controlled trials with narrative synthesis

2026

Human immunodeficiency virus (HIV) prevention has advanced substantially, yet ending new transmissions by 2030 remains uncertain. Pre-exposure prophylaxis (PrEP) has high biological efficacy, but real-world effectiveness varies due to adherence,...

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