SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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The effect of antiretroviral therapy with high central nervous system penetration on HIV-related cognitive impairment: A systematic review and meta-analysis

2022

Chronic complications are a significant concern for people living with HIV/AIDS (PLWHA) infection. HIV-associated neurocognitive disorders (HAND) are prevalent in PLWHA. Yet, the efficacy of medications that penetrate the central...

US Black cisgender women and pre-exposure prophylaxis for human immunodeficiency virus prevention: A scoping review

2022

Background: Black cisgender women in the United States experience a disproportionate burden of human immunodeficiency virus acquisition. Pre-exposure prophylaxis is an effective oral daily medication that reduces the risk of...

Risk of hepatitis C reinfection following successful therapy among people living with HIV: A global systematic review, meta-analysis, and meta-regression

2022

Background: The benefits of direct-acting antivirals towards the elimination of hepatitis C virus (HCV) in people living with HIV are decreased when individuals are reinfected with HCV following treatment. We aimed...

Peer approaches to improve HIV care cascade outcomes: A scoping review focused on peer behavioral mechanisms

2022

PURPOSE OF REVIEW: There are three main components of peer-based approaches regardless of type: education, social support, and social norms. The purpose of this scoping review was to examine evidence...

Diagnostic accuracy of WHO screening criteria to guide lateral-flow lipoarabinomannan testing among HIV-positive inpatients: A systematic review and individual participant data meta-analysis

2022

Background: WHO recommends urine lateral-flow lipoarabinomannan (LF-LAM) testing with AlereLAM in HIV-positive inpatients only if screening criteria are met. We assessed the performance of WHO screening criteria and alternative screening tests/strategies...

Coagulation parameters in human immunodeficiency virus infected patients: A systematic review and meta-analysis

2022

Background Coagulation abnormalities are common complications of human immunodeficiency virus (HIV) infection. Highly active antiretroviral treatment (HAART) decreased the mortality of HIV but increased coagulopathies. HIV-related thrombocytopenia, prolonged prothrombin time...

A review of sexual transmitted infection rates among sexually assaulted patients that present for care

2022

BACKGROUND: Patients who experience sexual assault are at risk of adverse health outcomes including sexually transmitted infections (STI) and often present to various healthcare centers for post-assault care. Unfortunately, there...

HIV pre-exposure prophylaxis and its impact on the gut microbiome in men having sex with men

2022

HIV/AIDS still imposes a high epidemiological and societal burden. Together with antiretroviral therapy, pre-exposure prophylaxis (PrEP) represents a fundamental tool in the fight against HIV/AIDS. PrEP is considered effective and...

The benefits of psychosocial interventions for mental health in men who have sex with men living with HIV: A systematic review and meta-analysis

2022

Objective Men who have sex with men (MSM) living with HIV are more likely to suffer from mental health problems. They should be given adequate attention to treat and improve...

Risk of mortality in HIV-infected COVID-19 patients: A systematic review and meta-analysis

2022

Background The relationship between HIV infection and COVID-19 clinical outcomes remains a significant public health research problem. We aimed to determine the association of HIV comorbidity with COVID-19 mortality. Methods...

Glioblastoma multiforme in patients with human immunodeficiency virus: An integrated review and analysis

2022

Introduction: As lifespans for persons living with HIV (PLWH) have improved over the last decade, there has been a simultaneous increase in non-AIDS-related cancer in that group. However, there is a...

Burden of tuberculosis and hepatitis co-infection among people living with HIV in Nepal: A systematic review and meta-analysis

2022

People living with HIV (PLHIV) are prone to tuberculosis (TB) and hepatitis co-infections, which cause substantial burden on morbidity and mortality. However, data on the burden of HIV co-infection from...

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