SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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A scoping review on HCV screening strategies: Population to screen and the test types

2025

BACKGROUND: Hepatitis C virus (HCV) is a genetically diverse blood-borne pathogen causing liver inflammation and damage. It is one of the global public health problems responsible for claiming thousands of...

HIV, hepatitis, and syphilis self-testing among adolescents and young adults: A systematic review and meta-analysis

2025

Background: Adolescents and young adults (AYA) make up a significant share of the world’s burden of HIV and other sexually transmitted infections (STI). Self-testing can increase testing coverage and strengthen the...

The association between HIV infection and carotid intima-media thickness in the era of antiretroviral therapy: A meta-analysis

2025

Atherosclerosis remains a leading cause of mortality globally, and this is worse in people living with HIV (PLHIV). While the administration of antiretroviral therapy (ART) in this population has significant...

HIV-1 drug resistance in children and implications for pediatric treatment strategies: A systematic review and meta-analysis

2025

Introduction Failure in the prevention of mother-to-child HIV transmission (PMTCT) and pediatric treatment challenges led to pretreatment drug resistance (PDR) and acquired drug resistance (ADR) in children with HIV (CWHIV)....

Machine learning for personalized risk assessment of HIV, syphilis, gonorrhoea and chlamydia: A systematic review and meta-analysis

2025

Background Machine learning (ML) shows promise for sexually transmitted infection (STI) risk prediction, but systematic evidence of its effectiveness remains fragmented. Methods We systematically searched six electronic databases, three preprint...

Meta-analysis of TB & HIV co-infection mortality rate in sub-Saharan African children, youth, and adolescents

2025

Background Despite the effectiveness of antiretroviral treatment (ART) in reducing morbidity and mortality, children and adolescents with co-infections face an elevated risk of death due to their young age and...

Worldwide epidemiology of Cyclospora cayetanensis in HIV/AIDS patients: A systematic review and meta-analysis

2025

BACKGROUND: Cyclospora cayetanensis is a coccidian protozoan parasite belonging to the phylum Apicomplexa. This systematic review and meta-analysis aimed to assess the prevalence and risk factors of C. cayetanensis in...

Retention in HIV care among Southeast Asian people living with HIV: A systematic review and meta-analysis

2025

Background Despite the effectiveness of antiretroviral therapy (ART) in reducing HIV-related morbidity and mortality, the retention of HIV care remains suboptimal in Southeast Asia. Objective This systematic review and meta-analysis...

Evolving patterns of macrolide and fluoroquinolone resistance in Mycoplasma genitalium: An updated systematic review and meta-analysis

2025

Background: Over the past 5 years, since publication of the initial review, studies have provided additional data on macrolide and fluoroquinolone resistance in Mycoplasma genitalium, including data from regions previously lacking...

Social and structural determinants of health influencing HIV risk and participation across the HIV care cascade

2025

Key take-home messages

Doxycycline prophylaxis for the prevention of bacterial sexually transmitted infections (STIs): doxyPrEP and doxyPEP

2024

No abstract available

Immune responses to vaginal candidiasis in African women: A scoping review of cytokine profiles, T-cell activation, and gene expression

2025

Background Recent immunological studies of vaginal candidiasis in African populations have revealed complex host‒pathogen interactions with implications for therapeutic development and HIV acquisition risk. Objective This scoping review synthesized evidence...

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