SHARE is an easy-to-search, real-time repository of HIV-related systematic reviews. Whether you’re a researcher, community member, healthcare provider or policymaker, SHARE provides a ‘one-stop shop’ for HIV-related information that has been published through a systematic review.

In addition to systematic reviews published in peer reviewed journals, SHARE also includes Rapid Response reviews produced by the Ontario HIV Treatment Network (OHTN).

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Effectiveness of oral pre-exposure prophylaxis (PrEP) for HIV

2018

Key take-home messages Oral PrEP (tenofovir disoproxil fumarate with emtricitabine) is highly protective against HIV acquisition across various populations and across different dosing schedules. Open label and demonstration projects in...

Lamivudine plus tenofovir combination therapy versus lamivudine monotherapy for HBV/HIV coinfection: A meta-analysis

2018

BACKGROUND: Currently, there is no consensus on the efficacy and safety of lamivudine (LAM) plus tenofovir disoproxil fumarate (TDF) combination therapy versus lamivudine monotherapy in HBV/HIV coinfected patients. METHODS: A...

The global and regional prevalence, burden, and risk factors for methicillin-resistant Staphylococcus aureus colonization in HIV-infected people: A systematic review and meta-analysis

2018

BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is among the most important opportunistic pathogens in HIV+ patients, resulting in considerable morbidity and mortality. METHODS: The MEDLINE, Scopus, Web of Science, and EMBASE...

Effects of peer sexual health education on college campuses: A systematic review

2018

OBJECTIVE: College peer health education groups have grown in popularity to provide information about health and wellness topics. The purpose of this systematic review was to evaluate the effectiveness of...

The Impact of co-morbid severe mental illness and HIV upon mental and physical health and social outcomes: A systematic review

2018

Our aim was to review the evidence related to the impact of co-morbid severe mental illness SMI (schizophrenia, schizoaffective and bipolar disorder) and HIV upon mental health, physical health and...

Organ-specific toxicities due to radiation therapy in cancer patients with or without HIV infection: A systematic review of the literature

2018

Background: To synthesize published literature on the association between human immunodeficiency virus (HIV) infection and radiation therapy (RT)-related toxicities. Methods: Two electronic databases, MEDLINE and Embase, were searched to identify...

Individual patient data meta-analysis of randomized controlled trials of dual therapy with a boosted PI plus lamivudine for maintenance of virological suppression: GeSIDA study 9717

2018

Background: Dual therapy (DT) with a ritonavir-boosted PI (PI/r) plus lamivudine has proven non-inferior (12% margin) to triple therapy (TT) with PI/r plus two nucleos(t)ide reverse transcriptase inhibitors [N(t)RTIs] in...

Is alcohol use associated with increased risk of developing adverse health outcomes among adults living with human immunodeficiency virus: A systematic review

2018

BACKGROUND: Alcohol use is associated with many HIV-related behaviors that are associated with increased risk of reinfection, transmission, and poorer health outcomes in people living with HIV (PLHIV). The population...

Type-specific anal human papillomavirus prevalence among men, according to sexual preference and HIV status: A systematic literature review and meta-analysis

2018

Background: Anal human papillomavirus (HPV) infection, most notably of HPV16, the central cause of anal cancer, is increased by anal sexual intercourse and worsened by HIV-positivity. Methods: We undertook a...

How linked are national HIV and SRHR strategies? A review of SRHR and HIV strategies in 60 countries

2017

The connection between HIV and sexual and reproductive health and rights (SRHR) is widely recognised along with the benefits of linking them at the legal/policy, health systems, and service delivery...

Stroke in human immunodeficiency virus-infected individuals in Sub-Saharan Africa (SSA): A systematic review

2018

BACKGROUND: Human immunodeficiency virus (HIV) infection is associated with worse outcomes after stroke, but this association is less well-described in sub-Saharan Africa (SSA). We reviewed literature on stroke among people...

Effectiveness of short message services and voice call interventions for antiretroviral therapy adherence and other outcomes: A systematic review and meta-analysis

2018

BACKGROUND: The potential of using mobile phone technologies to improve antiretroviral therapy (ART) adherence has provided a new facet to human immunodeficiency virus (HIV) research. The quality of evidence and...

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