Category Archives: Other
Anogenital warts and other HPV-associated anogenital lesions in the HIV-positive patient: A systematic review and meta-analysis of the efficacy and safety of interventions assessed in controlled clinical trials
OBJECTIVES: Anogenital warts (AGW, condylomata acuminata) and intraepithelial neoplasia (IEN) do not only impact health and social well-being, they are also associated with considerable costs for the healthcare systems. Immunocompromised...
Does maternal HSV-2 coinfection increase mother-to-child transmission of HIV? A systematic review
BACKGROUND: Reducing HIV mother-to-child transmission (MTCT) is critical to ending the HIV pandemic. Reports suggest that herpes simplex virus-2 (HSV-2), a common coinfection in HIV-infected individuals, is associated with increased...
Pneumococcal conjugate vaccine in HIV-infected and HIV-exposed, uninfected children
INTRODUCTION: Incidence of invasive pneumococcal disease (IPD) among HIV-infected children is 20-40 fold greater compared to HIV-uninfected children, including among HIV-infected children on antiretroviral therapy (ART). Also, HIV-exposed, uninfected children...
Toxoplasma gondii infection in immunocompromised patients: A systematic review and meta-analysis
Toxoplasma gondii has been suggested as an important opportunistic pathogen in immunocompromised patients. We conducted a global meta-analysis to assess the prevalence and odds ratios (ORs) of T. gondii infection...
Carcinogenicity of human papillomavirus (HPV) types in HIV-positive women: A meta-analysis from HPV infection to cervical cancer
Background.: Data on the relative carcinogenic potential of human papillomavirus (HPV) types among women infected with human immunodeficiency virus (HIV) (WHIV) are needed to inform prevention programs for this population....
Candida antifungal drug resistance in sub-Saharan African populations: A systematic review
Background: Candida infections are responsible for increased morbidity and mortality rates in at-risk patients, especially in developing countries where there is limited access to antifungal drugs and a high burden...
Community-acquired pneumonia in HIV-positive patients: An update on etiologies, epidemiology and management
PURPOSE OF REVIEW: Community-acquired pneumonia (CAP) is the cause of a considerable burden of morbidity and mortality among HIV-infected patients. The purpose of this study was to review recent literature...
Prevalence and burden of toxoplasma gondii infection in HIV-infected people: A systematic review and meta-analysis
BACKGROUND: Worldwide, 30% of the world’s population have antibodies to the intracellular protozoan parasite Toxoplasma gondii and about 36.7 million people are infected with HIV, but little is known about...
The dynamic role of the IL-33/ST2 axis in chronic viral-infections: Alarming and adjuvanting the immune response
UNLABELLED: Interleukin 33 (IL-33), a member of the IL-1 family, is constitutively expressed in epithelial and in endothelial cells at barrier sites, acting as a danger signal and adjuvanting the...
Systematic review of outbreaks of Pneumocystis jirovecii pneumonia: Evidence that P. jirovecii is a transmissible organism and the implications for healthcare infection control
BACKGROUND: Pneumocystis jirovecii pneumonia (PCP) is an important cause of morbidity and mortality in immunocompromised patients. Several nosocomial outbreaks of PCP have been reported in human-immunodeficiency-virus-negative, immunocompromised patients. The primary...
