Category Archives: Tuberculosis
Prevalence of nontuberculous mycobacterium infections versus tuberculosis among autopsied HIV patients in sub-Saharan Africa: A systematic review and meta-analysis
In industrialized countries, Mycobacterium avium complex and other nontuberculous mycobacteria (NTM) are major causes of opportunistic infection-related deaths in HIV patients. However, in resource-limited regions, data on NTM are scarce,...
Oral candidiasis prevalence in human immunodeficiency virus-1 and pulmonary tuberculosis coinfection: A systematic review and meta-analysis
BACKGROUND: Human immunodeficiency virus-1 (HIV-1) infected people are more likely to develop tuberculosis (TB), being the leading cause of death in HIV-1. Candida spp has emerged as potential pathogenic fungi...
A systematic review of utility of urine lipoarabinomannan in detecting tuberculosis among HIV-positive tuberculosis suspects
Sputum smear microscopy (SSM), though regarded as an inexpensive and popular method for detecting tuberculosis (TB), lacks adequate sensitivity, specifically in adult people living with HIV/AIDS (PLHIV). Urine lipoarabinomannan (LAM)...
Isoniazid preventive therapy plus antiretroviral therapy for the prevention of tuberculosis: A systematic review and meta-analysis of individual participant data
Background: Isoniazid preventive therapy prevents active tuberculosis in people with HIV, but previous studies have found no evidence of benefit in people with HIV who had a negative tuberculin skin...
HIV infection and multidrug resistant tuberculosis: a systematic review and meta-analysis
BACKGROUND: Multidrug-resistant tuberculosis (MDR-TB) in HIV infected individuals is a serious threat to global efforts to combat tuberculosis. Inconsistent findings on the association between HIV infection and MDR-TB were present...
A systematic review on the effect of HIV infection on the pharmacokinetics of first-line tuberculosis drugs
INTRODUCTION: Contrasting findings have been published regarding the effect of human immunodeficiency virus (HIV) on tuberculosis (TB) drug pharmacokinetics (PK). OBJECTIVES: The aim of this systematic review was to investigate...
Pharmacokinetics of antiretroviral and tuberculosis drugs in children with HIV/TB co-infection: a systematic review
INTRODUCTION: Management of concomitant use of ART and TB drugs is difficult because of the many drug-drug interactions (DDIs) between the medications. This systematic review provides an overview of the...
Transmission dynamics in tuberculosis patients with human immunodeficiency Virus: A systematic review and meta-analysis of 32 observational studies
BACKGROUND: There are large knowledge gaps on the transmission dynamics of Mycobacterium tuberculosis in settings where both tuberculosis and HIV are endemic. We aimed to assess the infectiousness of tuberculosis...
Intestinal parasites and HIV in Ethiopian tuberclosis patients: A systematic review and meta-analysis
BACKGROUND: The distribution of intestinal parasites among patients with tuberculosis in Ethiopia is not well understood. OBJECTIVE: This systematic review and meta-analysis was designed to determine the pooled national prevalence...
Implications of COVID-19 in high burden countries for HIV/TB: A systematic review of evidence
BACKGROUND: The triple burden of COVID-19, tuberculosis and human immunodeficiency virus is one of the major global health challenges of the twenty-first century. In high burden HIV/TB countries, the spread...
Unknown HIV status and the TB/HIV collaborative control program in Ethiopia: Systematic review and meta-analysis
BACKGROUND: Ethiopia has shown significant efforts to address the burden of TB/HIV comorbidity through the TB/HIV collaborative program. However, these diseases are still the highest cause of death in the...
Tuberculosis and its association with CD4(+) T cell count among adult HIV positive patients in Ethiopian settings: A systematic review and meta-analysis
BACKGROUND: Tuberculosis (TB) and HV have been intertwined and makeup a deadly human syndemic worldwide, especially in developing countries like Ethiopia. Previous studies have reported different TB incidences and its...
