Category Archives: Cardiovascular
Lights and shadows of microbiota modulation and cardiovascular risk in HIV patients
Human immunodeficiency virus (HIV) infection is associated with premature aging and the development of aging-related comorbidities, such as cardiovascular disease (CVD). Gut microbiota (GM) disturbance is involved in these comorbidities...
Association of HIV infection and antiretroviral therapy With arterial stiffness: A systematic review and meta-analysis
Incidence of cardiovascular disease in people living with HIV has increased as overall survival has improved because of combination antiretroviral therapy (cART). Arterial stiffness is a composite indicator of cardiovascular...
Cardiovascular risks associated with protease inhibitors for the treatment of HIV
Introduction: Cumulative use of some first-generation protease inhibitors has been associated with higher rates of dyslipidemia and increased risk of cardiovascular disease. The protease inhibitors most commonly in use are...
Course of disease and clinical outcome of infective endocarditis in HIV-infected individuals: A systematic review and meta-analysis
Infective endocarditis (IE) causes substantial morbidity and mortality if untreated. The clinical course of IE might be different in HIV-positive patients as a result of immune dysfunction. This systematic review...
Prevalence of cardiometabolic syndrome in HIV-infected persons: A systematic review
Introduction: HIV infected persons are twofold likely to experience a heart attack, stroke, and other forms of Cardiometabolic Syndrome (CMetS). Methods: Electronic searches of databases (MEDLINE and Google Scholar) were queried for...
Overweight and obesity among adult HIV infected peoples receiving ART in Ethiopia: A systematic review and meta-analysis
BACKGROUND: Over-nutrition and diet-linked non-communicable morbidities are showing increasing trend overtime. Even if there are different factors that affect the change in BMI other than ART, several authors have reported...
Dangerous liaisons? The role of inflammation and comorbidities in HIV and SARS-CoV-2 infection
INTRODUCTION: In people living with HIV (PLWH), immune activation and inflammation levels are high even when viral suppression is maintained, potentially contributing to several comorbidities, and hampering the immune response...
Impact of advanced HIV disease on quality of life and mortality in the era of combined antiretroviral treatment
Currently, AIDS or severe immunodeficiency remains as a challenge for people with HIV (PWHIV) and healthcare providers. Our purpose was to analyze the impact of advanced HIV disease (AHD) on...
Adjunct therapy for CD4(+) T-cell recovery, inflammation and immune activation in people living With HIV: A systematic review and meta-analysis
Background: HIV infection results in immune homeostasis perturbations, which is characterized by CD4(+) T-cell depletion, immune activation, and inflammation. Effective antiretroviral therapy (ART) does not fully restore immunologic and clinical...
Human Immunodeficiency Virus infection and diverse physical health outcomes: An umbrella review of meta-analyses of observational studies
BACKGROUND: Our aim was to assess both the credibility and strength of evidence arising from systematic reviews with meta-analyses of observational studies and physical health outcomes associated with human immunodeficiency...
