Category Archives: Co-morbidities

HIV protease inhibitors and insulin sensitivity: A systematic review and meta-analysis of randomized controlled trials

2021

Background: Protease inhibitors (PIs) are believed to affect insulin sensitivity. We aimed to analyze the effect of PIs on insulin sensitivity and the onset of diabetes mellitus (DM) in patients with...

Prevalence of oral lesions in patients with AIDS: A systematic review and meta-analysis

2021

Background Oral lesions are considered to be early clinical signs which may predict the progression of patients with acquired immune deficiency syndrome (AIDS). Due to the lack of a comprehensive...

Patient perspectives on integrated healthcare for HIV, hypertension and type 2 diabetes: A scoping review

2021

INTRODUCTION: Antiretroviral therapy has reduced mortality and led to longer life expectancy in people living with HIV. These patients are now at an increased risk of non-communicable diseases (NCDs). Integration...

Sex differences in non-AIDS comorbidities among people with human immunodeficiency virus

2021

Women are grossly underrepresented in human immunodeficiency virus (HIV) clinical and translational research. This is concerning given that people with HIV (PWH) are living longer, and thus accumulating aging-related non-AIDS...

Diabetes mellitus among adults on highly active anti-retroviral therapy and its associated factors in Ethiopia: Systematic review and meta-analysis

2021

Background Diabetes mellitus occurs as a comorbid illness among people living with HIV and, in particular those on Highly Active Anti-retroviral therapies (HAART). Previous studies have documented the prevalence of...

Human immunodeficiency virus infection promotes human papillomavirus-mediated anal squamous carcinogenesis: An immunologic and pathobiologic review

2022

BACKGROUND: Anal squamous cell carcinoma (SCC) is a rare gastrointestinal malignancy with rising incidence, both in the United States and internationally. The primary risk factor for anal SCC is human...

Characteristics and impacts of nutritional programmes to address undernutrition of adults living with HIV in sub-Saharan Africa: A systematic review of evidence

2022

OBJECTIVES: Although some studies have identified various challenges affecting nutritional programmes to effectively tackle undernutrition among people living with HIV, evidence about the characteristics and impacts of these programmes on...

Risk factors for COVID-19 mortality among people living with HIV: A scoping review

2022

People living with HIV (PLWH) are particularly vulnerable to worsened outcomes of COVID-19. Therefore, the purpose of this work was to provide a scoping review of the literature to assess...

Impact of combined antiretroviral therapy on metabolic syndrome components in adult people living with HIV: A literature review

2022

The development of metabolic derangements as a result of HIV treatment has been an important area of research since the introduction of zidovudine in the 1980’s. Antiretroviral therapy has intensely...

Loco-regional treatments for hepatocellular carcinoma in people living with HIV

2022

Hepatocellular carcinoma (HCC) accounts for approximately 75–90% of primary liver cancers and is the sixth most common cancer and the third leading cause of cancer-related deaths worldwide. In the HIV-positive...

Potential immune modulatory effect of vitamin D in HIV infection: A review

2021

Vitamin D is a fat soluble hormone that is majorly involved in the classical function of calcium and phosphorus hemostasis and bone mineralization as well non classical functions of immune...

Frailty in people living with HIV: An update

2022

PURPOSE OF REVIEW: The HIV population is ageing with rising rates of frailty though strategies of how best to manage it remain ill-defined. It also remains unclear what the prevalence...

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