Category Archives: Epidemiology and Determinants of Health
Deep vein thrombosis in adults with HIV: A systematic review and meta-analysis of prevalence and risk factors
Deep vein thrombosis (DVT) is a preventable yet serious complication among people living with human immunodeficiency virus (PLWH), attributed to hypercoagulability, low CD4+ counts, and antiretroviral therapy. Despite the high...
Challenges to physical activity participation among older people living with HIV: Scoping review
Older people living with Human Immunodeficiency Virus (OPLWH) have lower physical activity levels than other population groups. Inadequate physical activity participation increases the risks of age-related non-communicable diseases (NCDs). Therefore,...
Prevalence and factors associated with HIV viral rebound in individuals on ART: A systematic review study
BACKGROUND: Viral rebound (VR), the resurgence of detectable human immunodeficiency virus (HIV) viral loads (> 50 copies/mL) after suppression, remains a challenge for individuals on antiretroviral therapy (ART) in South...
Single-session interventions to enhance HIV outcomes among adolescents and young adults: A systematic scoping review and implications for integrating HIV and mental health services
Significant progress has been made in HIV prevention and treatment for adolescents and young adults (AYA), but integrating mental healthcare remains essential to address risks and improve treatment engagement. Single-session...
Probability of vertical HIV transmission: A systematic review and meta-regression
Background Eliminating HIV vertical transmission is a global priority and monitored by estimating paediatric HIV infections with the UNAIDS-supported Spectrum AIDS Impact Module (Spectrum-AIM). Recent innovations in antiretroviral therapy (ART)...
State of HIV research in Venezuela: A systematic review
BACKGROUND: Venezuela’s recent economic and political instability has severely compromised its healthcare infrastructure, impacting the management of infectious diseases, including human immunodeficiency virus (HIV). This disruption hinders progress towards the...
Network meta-analytical investigations of the performance of HIV combination prevention strategies for Indigenous populations
BACKGROUND: Indigenous populations worldwide face a disproportionate burden of HIV due to structural inequities, cultural marginalization, and limited access to health services. Despite growing recognition of the need for culturally...
Cost-effectiveness of HIV prevention strategies: A systematic review of economic evaluations
BACKGROUND: HIV/AIDS continues to pose a significant global health challenge, especially in low- and middle-income countries. Economic evaluations are essential to identify cost-effective prevention strategies and allocate limited healthcare resources...
Rapid start with bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) as initial treatment in people with human immunodeficiency virus-1 (HIV-1): A systematic literature review of clinical and patient-reported outcomes
BACKGROUND: Treatment guidelines recommend rapid antiretroviral therapy (ART) initiation among eligible people with HIV to improve treatment outcomes and reduce HIV transmission. Bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF), an integrase strand transfer inhibitor-based...
Cost-effectiveness of HIV prevention interventions in sub-Saharan Africa (2019-2025): A systematic review
INTRODUCTION: This systematic review synthesizes recent evidence on the cost-effectiveness of HIV prevention interventions in sub-Saharan Africa (SSA), where over 70% of the global HIV burden resides. METHODS: Following PRISMA...
HIV-related mortality time trends among children and young adolescents on antiretroviral therapy by age, treatment duration, and region: A systematic review and meta-regression analysis
Background: Past cohort studies have examined mortality among children and young adolescents (aged 0–14 years) who have received antiretroviral therapy (ART), but no systematic reviews have been undertaken to synthesise these...
