Category Archives: Neurocognitive disorders
Altered white matter integrity in the corpus callosum in adults with HIV: A systematic review of diffusion tensor imaging studies
We systematically reviewed studies comparing differences in the integrity of the corpus callosum in adults with HIV compared to healthy controls, using Diffusion Tensor Imaging (DTI), using search engines Science...
The global burden of cognitive impairment in people living with HIV: A systematic review and meta-analysis
Objective: While life expectancies of people with HIV (PWH) have increased through the successes of antiretroviral treatment, cognitive impairment remains a pressing concern. Prevalence estimates vary worldwide as different definitions for...
Epstein-Barr virus detection in the central nervous system of HIV-infected patients
Simply detecting Epstein-Barr virus deoxyribonucleic acid (EBV-DNA) is insufficient to diagnose EBV-associated diseases. The current literature around EBV-DNA detection from cerebrospinal fluid (CSF) in human immunodeficiency virus (HIV)-positive non-lymphoma patients...
HIV antiretroviral medication neuropenetrance and neurocognitive outcomes in HIV+ adults: A review of the literature examining the central nervous system penetration effectiveness score
This literature review summarizes the existing research examining the CNS penetration effectiveness (CPE) score and neurocognitive outcomes (i.e., neuropsychological assessment and neurocognitive screening) in HIV+ individuals. Despite the effectiveness of...
The effect of antiretroviral therapy with high central nervous system penetration on HIV-related cognitive impairment: A systematic review and meta-analysis
Chronic complications are a significant concern for people living with HIV/AIDS (PLWHA) infection. HIV-associated neurocognitive disorders (HAND) are prevalent in PLWHA. Yet, the efficacy of medications that penetrate the central...
Worldwide occurrence of HIV-associated neurocognitive disorders and its associated factors: A systematic review and meta-analysis
BACKGROUND: HIV-associated neurocognitive disorders are common in people living with HIV/AIDS and affect the adherence of patients to prescriptions, activities of daily living, and quality of life of patients. However,...
Central nervous system and neurodevelopmental outcomes of HIV + and HIV exposed children: A mini review of recent findings and lessons learned from the field
There has been an increase in research looking at neurodevelopmental/neurologic outcomes of children living with HIV (Children LWHIV) and HIV exposed but uninfected children (HEU) during an era of ART....
A meta-analytic review of the effect of antiretroviral therapy on neurocognitive outcomes in adults living with HIV-1 in low-and middle-income countries
HIV-associated neurocognitive impairment remains a challenge even in the era of antiretroviral therapy (ART). Over 90% of people living with HIV are in low- and middle-income countries. Hence, it is...
Impact of HIV-associated cognitive impairment on functional independence, frailty and quality of life in the modern era: A meta-analysis
HIV-associated neurocognitive disorder (HAND) is an important sequela of HIV infection. Combined antiretroviral therapy (cART) has improved the health outcomes of many people living with HIV but has given rise...
Meta-analysis on nicotine’s modulation of HIV-associated dementia
HIV-Associated Dementia (HAD) is a significant comorbidity that many HIV-patients face. Our study utilized QIAGEN Ingenuity Pathway Analysis (IPA) to identify and analyze molecular profiles and pathways underlying nicotine’s impact...
