Category Archives: Neurocognitive disorders

A systematic review of magnetic resonance imaging studies in perinatally HIV-infected individuals

2021

Over the past few years, neuroimaging studies have been performed in young adults with perinatally acquired HIV (PHIV) to study the impact of HIV infection on the central nervous system...

Association between education level and HIV-associated neurocognitive disorder: A systematic review and meta-analysis

2020

In the era of antiretroviral treatment, human immunodeficiency virus (HIV)-associated neurocognitive disorder (HAND) is common in HIV-positive (HIV+) patients, with an incidence of 30-50%. The relationship between education level and...

The impact of antiretroviral therapy on neurocognitive outcomes among people living with HIV in low- and middle-income countries (LMICs): A systematic review

2021

Low and middle-income countries (LMICs) are the epicenter of the HIV epidemic. The scale-up of antiretroviral therapy (ART) has reduced mortality, but HIV-associated neurocognitive impairment (HANI) remains prevalent, which impacts...

Is there any evidence of premature, accentuated and accelerated aging effects on neurocognition in people living with HIV? A systematic review

2021

Despite evidence of premature, accentuated and accelerated aging for some age-related conditions such as cardiovascular diseases in people living with HIV (PLHIV), the evidence for these abnormal patterns of aging...

Medical cannabis for chronic noncancer pain: A systematic review of health care recommendations

2021

Purpose. Medical cannabis for patients with chronic noncancer pain (CNCP) has been the focus of numerous health care recommendations. We conducted a systematic review to identify and summarize the currently...

Association of HIV infection and cognitive impairment in older adults: A meta-analysis

2021

Objective: To synthesize evidence on the association between human immunodeficiency virus (HIV) infection and cognitive impairment in older adults. Design: Meta-analysis. Participants: Adults aged 50 years or older. Methods: In this systematic literature review and meta-analysis, we...

Falls in people living with HIV: A scoping review

2020

OBJECTIVES: Recent research has indicated seemingly increased propensity for falls and accelerated bone demineralisation in people living with HIV (PLWH). We aim to map out the extent and nature of...

Human immunodeficiency virus-related peripheral neuropathy: A systematic review and meta-analysis

2020

Background and purpose: Human immunodeficiency virus (HIV)-associated neurological syndromes occur in affected individuals as a consequence of primary HIV infection, opportunistic infections, inflammation and as an adverse effect of some...

HIV, vascular risk factors, and cognition in the combination antiretroviral therapy era: A systematic review and meta-analysis

2020

OBJECTIVES: Mounting evidence indicates that vascular risk factors (VRFs) are elevated in HIV and play a significant role in the development and persistence of HIV-associated neurocognitive disorder. Given the increased...

Frequency of falls and associated risk factors in people living with HIV: a systematic review with meta-analysis and meta-regression

2020

BACKGROUND: Falls are considered predictive marker of poorer outcomes for people living with HIV. However, the available evidences on the predictive value of falls are controversial. Our aim is to...

The prevalence of Frascati-criteria-based HIV-associated neurocognitive disorder (HAND) in HIV-Infected adults: A systematic review and meta-analysis

2020

Background: The HIV associated mortality is decreasing in most countries due to the widespread use of antiretroviral therapy. However, HIV-associated neurocognitive disorder (HAND) remains a problematic issue that lowers the...

Proteomics and metabolomics of HIV-associated neurocognitive disorders: A systematic review

2021

HIV-associated neurocognitive disorders (HAND) are common features of the effect of human immunodeficiency virus (HIV)-1 within the central nervous system (CNS). The underlying neuropathophysiology of HAND is incompletely known. Furthermore,...

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