Category Archives: Neurocognitive disorders
Is there any evidence of premature, accentuated and accelerated aging effects on neurocognition in people living with HIV? A systematic review
Despite evidence of premature, accentuated and accelerated aging for some age-related conditions such as cardiovascular diseases in people living with HIV (PLHIV), the evidence for these abnormal patterns of aging...
Association of HIV infection and cognitive impairment in older adults: A meta-analysis
Objective: To synthesize evidence on the association between human immunodeficiency virus (HIV) infection and cognitive impairment in older adults. Design: Meta-analysis. Participants: Adults aged 50 years or older. Methods: In this systematic literature review and meta-analysis, we...
Medical cannabis for chronic noncancer pain: A systematic review of health care recommendations
Purpose. Medical cannabis for patients with chronic noncancer pain (CNCP) has been the focus of numerous health care recommendations. We conducted a systematic review to identify and summarize the currently...
Human immunodeficiency virus-related peripheral neuropathy: A systematic review and meta-analysis
Background and purpose: Human immunodeficiency virus (HIV)-associated neurological syndromes occur in affected individuals as a consequence of primary HIV infection, opportunistic infections, inflammation and as an adverse effect of some...
HIV, vascular risk factors, and cognition in the combination antiretroviral therapy era: A systematic review and meta-analysis
OBJECTIVES: Mounting evidence indicates that vascular risk factors (VRFs) are elevated in HIV and play a significant role in the development and persistence of HIV-associated neurocognitive disorder. Given the increased...
Frequency of falls and associated risk factors in people living with HIV: a systematic review with meta-analysis and meta-regression
BACKGROUND: Falls are considered predictive marker of poorer outcomes for people living with HIV. However, the available evidences on the predictive value of falls are controversial. Our aim is to...
The prevalence of Frascati-criteria-based HIV-associated neurocognitive disorder (HAND) in HIV-Infected adults: A systematic review and meta-analysis
Background: The HIV associated mortality is decreasing in most countries due to the widespread use of antiretroviral therapy. However, HIV-associated neurocognitive disorder (HAND) remains a problematic issue that lowers the...
Proteomics and metabolomics of HIV-associated neurocognitive disorders: A systematic review
HIV-associated neurocognitive disorders (HAND) are common features of the effect of human immunodeficiency virus (HIV)-1 within the central nervous system (CNS). The underlying neuropathophysiology of HAND is incompletely known. Furthermore,...
Association between cognitive reserve and cognitive performance in people with HIV: A systematic review and meta-analysis
Cognitive reserve is a potential explanation for the disparity between brain pathology and its clinical manifestations. The main objective of this study was to estimate, based on published studies, the...
Cognitive and educational interventions for orphans and vulnerable children affected by HIV/AIDS: A meta-analysis
Orphans and vulnerable children affected by HIV/AIDS (HIV OVC) are at risk for cognitive difficulties and lack of access to education. Interventions addressing cognitive or educational outcomes for HIV OVC...