Category Archives: Neurocognitive disorders

Proteomics and metabolomics of HIV-associated neurocognitive disorders: A systematic review

2021

HIV-associated neurocognitive disorders (HAND) are common features of the effect of human immunodeficiency virus (HIV)-1 within the central nervous system (CNS). The underlying neuropathophysiology of HAND is incompletely known. Furthermore,...

Association between cognitive reserve and cognitive performance in people with HIV: A systematic review and meta-analysis

2020

Cognitive reserve is a potential explanation for the disparity between brain pathology and its clinical manifestations. The main objective of this study was to estimate, based on published studies, the...

Cognitive and educational interventions for orphans and vulnerable children affected by HIV/AIDS: A meta-analysis

2020

Orphans and vulnerable children affected by HIV/AIDS (HIV OVC) are at risk for cognitive difficulties and lack of access to education. Interventions addressing cognitive or educational outcomes for HIV OVC...

Neuropathy complication of antiretroviral therapy in HIV/AIDS patients

2020

OBJECTIVES: Significant pain from HIV-associated sensory neuropathy (HIV-SN) affects 40% of HIV-infected individuals treated with antiretroviral therapy (ART). The most salient symptom of the neuropathy is pain, which frequently is...

Cognitive and neurologic rehabilitation strategies for central nervous system HIV infection

2020

PURPOSE OF REVIEW: Cognitive impairment leading to disability is increasingly seen in people living with human immunodeficiency virus (PLWH). Rehabilitation can alleviate the effects of cognitive impairment upon function. The...

Interventions for Children with Neurocognitive Impairments in Resource-Limited Settings: A Systematic Review

2020

Many children and adolescents around the world suffer from neurocognitive deficits due to chronic disorders, such as Human Immunodeficiency Virus (HIV) and malaria. Resource-limited settings exacerbate the risk of negative...

Global prevalence and burden of HIV-associated neurocognitive disorder: A meta-analysis

2020

OBJECTIVES: We aimed to characterise the prevalence and burden of HAND and assess associated factors in the global population with HIV. METHODS: We searched PubMed and Embase for cross-sectional or...

The relationship between potentially traumatic or stressful events, HIV infection and neurocognitive impairment (NCI): A systematic review of observational epidemiological studies

2020

BACKGROUND: HIV/AIDS and potentially traumatic events (PTEs) or stressful life events (SLEs) and/or PTSD are independently associated with neurocognitive impairment (NCI). Literature suggests that HIV and PTE/SLE exposure independently and...

Mental health research in Botswana: a semi-systematic scoping review

2020

Mental and substance use disorders are a leading cause of disability worldwide. Despite this, there is a paucity of mental health research in low- and middle-income countries, especially in sub-Saharan...

Antiretroviral therapy improves neurocognitive impairment in people living with HIV? A meta-analysis

2020

Objectives: Although effective antiretroviral therapy (ART) has been used for more than two decades, HIV-associated neurocognitive disorder remains prevalent. Thus, whether ART can improve neurocognitive impairment is controversial. This review...

Peripheral immune dysregulation in the ART era of HIV-associated neurocognitive impairments: A systematic review

2020

Human immunodeficiency virus-associated neurocognitive impairment (HANI) remains problematic despite the effective use of antiretroviral therapy (ART) and viral suppression. A dysregulated immune response contributes to the development of HANI but...

Physical activity and cognitive health among people living with HIV: An integrative review

2019

The purpose of our review was to analyze evidence related to physical activity (PA) and cognitive health in people living with HIV (PLWH), appraise psychometric characteristics of study measures, and...

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