Category Archives: Population(s)
Clostridium difficile in immunocompromised hosts: A review of epidemiology, risk factors, treatment, and prevention
Clostridium difficile is a significant pathogen in healthcare today, impacting both hospitalized and community-based patients. Immunocompromised patients experience a high incidence of C. difficile infection, ranging from 6% to 33%...
The pharmacogenetics of efavirenz metabolism in children: The potential genetic and medical contributions to child development in the context of long-term ARV treatment
Efavirenz (EFV) is a well-known, effective anti-retroviral drug long used in first-line treatment for children and adults with HIV and HIV/AIDS. Due to its narrow window of effective concentrations, between...
Informing the measurement of wellbeing among young people living with HIV in sub-Saharan Africa for policy evaluations: A mixed-methods systematic review
Young people living with HIV (YPLHIV) in sub-Saharan Africa (SSA) are at high risk of having a poor quality of life. Addressing wellbeing explicitly within HIV/AIDS policies could assist mitigation...
Impact of mobile phone-based interventions on methamphetamine use and high-risk sexual behaviors in men who have sex with men (MSM): A systematic review
Background: Today, increased use of methamphetamine in homosexual men is associated with high-risk sexual behaviors and (HIV) epidemic. Mobile phone-based interventions are an accessible and rapid method to provide healthcare...
A review of usability evaluation methods and their use for testing eHealth HIV interventions
PURPOSE OF REVIEW: To provide a comprehensive review of usability testing of eHealth interventions for HIV. RECENT FINDINGS: We identified 28 articles that assessed the usability of eHealth interventions for...
Systematic review and meta-analysis of global prevalence of HBsAg and HIV and HCV antibodies among people who inject drugs and female sex workers
The main objective of this study was to evaluate the prevalence of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS), hepatitis C virus (HCV) and hepatitis B virus (HBV) and their co-infections...
Cryptococcal antigenemia and its predictors among HIV infected patients in resource limited settings: A systematic review
BACKGROUND: Cryptococcosis is an opportunistic fungal infection that primarily affects people with advanced HIV/AIDS and is an important cause of morbidity and mortality around the globe. By far the most...
Injecting risk behaviours amongst people who inject drugs: A global multi-stage systematic review and meta-analysis
BACKGROUND: Injecting risk behaviour, such as receptive sharing of injecting equipment and/or re-using one’s equipment, is associated with bloodborne virus transmission and infections in people who inject drugs (PWID). We...
Direct-acting antivirals for HCV treatment in older patients: A systematic review and meta-analysis
The advent of highly effective and well-tolerated direct antiviral antivirals (DAAs) has dramatically changed the landscape of chronic hepatitis C. The effect of DAAs in older adults is difficult to...
