Category Archives: Population(s)
Progressive multifocal leukoencephalopathy in patients treated with fumaric acid esters: A review of 19 cases
Progressive multifocal leukoencephalopathy (PML) is a rare and potentially fatal condition caused by a brain infection with JC polyomavirus (JCV). PML develops almost exclusively in immunocompromised patients and has recently...
Incidence and prevalence of bacteriologically confirmed pulmonary tuberculosis among adolescents and young adults: A systematic review
The burden of tuberculosis (TB) among adolescents and young adults in endemic settings is poorly characterised. This study aimed to review published and unpublished estimates of the incidence and prevalence...
Comorbidities and treatment outcomes in multidrug resistant tuberculosis: A systematic review and meta-analysis
Little is known about the impact of comorbidities on multidrug resistant (MDR) and extensively drug resistant (XDR) tuberculosis (TB) treatment outcomes. We aimed to examine the effect of human immunodeficiency...
From CD4-based initiation to treating all HIV-infected adults immediately: An evidence-based meta-analysis
Background: The World Health Organization (WHO) Consolidated antiretroviral therapy (ART) guidelines set the CD4(+) T-cell counts threshold to 500 cells/mm(3) in 2013, and 2015 guidelines recommend treating all HIV-infected adults...
Physiotherapy for people with mental health problems in Sub-Saharan African countries: A systematic review
Background: There is a need for psychosocial interventions to address the escalating mental health burden in Sub-Saharan Africa (SSA). Physiotherapists could have a central role in reducing the burden and...
Meeting the reproductive health needs of female key populations affected by HIV in low- and middle-income countries: A review of the evidence
Female sex workers and other women at high risk of acquiring HIV have the right to sexual and reproductive health, including the right to determine the number and timing of...
How should HIV resources be allocated? Lessons learnt from applying Optima HIV in 23 countries
INTRODUCTION: With limited funds available, meeting global health targets requires countries to both mobilize and prioritize their health spending. Within this context, countries have recognized the importance of allocating funds...
Prevalence of sexually transmitted infections and bacterial vaginosis among women in sub-Saharan Africa: An individual participant data meta-analysis of 18 HIV prevention studies
BACKGROUND: Estimates of sexually transmitted infection (STI) prevalence are essential for efforts to prevent and control STIs. Few large STI prevalence studies exist, especially for low- and middle-income countries (LMICs)....
Scoping out the literature on mobile needle and syringe programs-review of service delivery and client characteristics, operation, utilization, referrals, and impact
BACKGROUND: Needle and syringe program (NSP) service delivery models encompass fixed sites, mobile services, vending machines, pharmacies, peer NSPs, street outreach, and inter-organizational agreements to add NSP services to other...
Prevalence and risk factors of nonalcoholic fatty liver disease in HIV-monoinfection
OBJECTIVE: To identify the prevalence and risk factors of nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH) and fibrosis in HIV-monoinfected patients. DESIGN: Systematic review and meta-analysis. METHODS: We searched...
Reliability of HIV rapid diagnostic tests for self-testing compared with testing by health-care workers: A systematic review and meta-analysis
BACKGROUND: The ability of individuals to use HIV self-tests correctly is debated. To inform the 2016 WHO recommendation on HIV self-testing, we assessed the reliability and performance of HIV rapid...
